Impact of brain-derived neurotrophic factor Val66Met polymorphism on cortical thickness and voxel-based morphometry in healthy Chinese young adults

PloS One
Xuejuan YangJie Tian

Abstract

Following voxel-based morphometry (VBM), brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) has been shown to affect human brain morphology in Caucasians. However, little is known about the specific role of the Met/Met genotype on brain structure. Moreover, the relationship between BDNF Val66Met polymorphism and Chinese brain morphology has not been studied. The present study investigated brain structural differences among three genotypes of BDNF (rs6265) for the first time in healthy young Chinese adults via cortical thickness analysis and VBM. Brain differences in Met carriers using another grouping method (combining Val/Met and Met/Met genotypes into a group of Met carriers as in most previous studies) were also investigated using VBM. Dual-approach analysis revealed less gray matter (GM) in the frontal, temporal, cingulate and insular cortices in the Met/Met group compared with the Val/Val group (corrected, P<0.05). Areas with less GM in the Val/Met group were included in the Met/Met group. VBM differences in Met carriers were only found in the middle cingulate cortex. The current results indicated a unique pattern of brain morphologic differences caused by BDNF (rs6265) in young Chinese adults, in whic...Continue Reading

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Datasets Mentioned

BETA
GM

Methods Mentioned

BETA
PCRs
PCR
electrophoresis

Related Concepts

Alleles
Insula of Reil
Magnetization Transfer Contrast Imaging
Pedameth
Genetic Polymorphism
Valine
Brain-Derived Neurotrophic Factor
Brain
Cerebral Cortex
Drug Carriers

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