Abstract
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic fever in China, Korea, and Japan. Japanese spotted fever (JSF), which belongs to spotted fever group rickettsioses, is also endemic to Western Japan. Patients with SFTS and those with JSF display many of the same clinical manifestations. Sudden fever, rash, tick bite, and neurological and gastrointestinal symptoms may be seen in both infections, but the frequency and severity of each disease have not been compared and studied. Because laboratory confirmation of pathogens takes time, it is important to predict diagnosis of SFTS vs JSF based on the features of the clinical characteristics at the initial presentation, particularly in primary care settings. We conducted a case series review at 4 medical facilities in Miyazaki, Japan. Based on the medical records, clinical and laboratory characteristics were compared between patients with SFTS and those with JSF. Eighty-one patients were enrolled in this study, including 41 with SFTS and 40 with JSF. The absence of rash (P < .001), leukopenia (P < .001), and normal C-reactive protein (CRP) levels (P < .001) were the variables distinguishing SFTS from JSF. Normal CRP levels (≤1.0 mg/dL) had a 95% sens...Continue Reading
References
Jan 1, 1986·Microbiology and Immunology·T UchidaY Kitamura
Nov 1, 1985·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·F MaharaT Uchiyama
Feb 1, 1995·Journal of Clinical Microbiology·Y FuruyaI Kaiho
Jul 14, 2006·Emerging Infectious Diseases·Moon-Hyun ChungJae-Seung Kang
Jun 15, 2007·Emerging Infectious Diseases·Jariyanart GayweeNarongrid Sirisopana
Mar 18, 2011·The New England Journal of Medicine·Xue-Jie YuDe-Xin Li
Nov 19, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zhongtao GaiDexin Li
Aug 21, 2012·The Journal of Infectious Diseases·Yulan SunDexin Li
Oct 22, 2016·Emerging Infectious Diseases·Qing-Bin LuWu-Chun Cao
Oct 25, 2016·PloS One·Hirofumi KatoUNKNOWN SFTS epidemiological research group-Japan
Dec 30, 2016·PLoS Neglected Tropical Diseases·Seong Jin ChoiUNKNOWN for Korea SFTS Clinical Network
Aug 19, 2017·The American Journal of Tropical Medicine and Hygiene·Jesus A Silvas, Patricia V Aguilar
Jan 3, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Min-Chul KimSung-Han Kim
Jul 29, 2018·The Lancet Infectious Diseases·Hao LiWei Liu
Aug 14, 2018·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Masayuki Saijo
Aug 21, 2018·Emerging Infectious Diseases·Eiichiro SandoKoya Ariyoshi
Jan 9, 2019·Nature Microbiology·Younho ChoiJae U Jung
Feb 21, 2019·BMC Infectious Diseases·Sang-Won ParkMyoung-Don Oh
Aug 24, 2019·Emerging Infectious Diseases·Hao LiWei Liu
Sep 25, 2019·The American Journal of Tropical Medicine and Hygiene·Sang Hyun RaSung-Han Kim
Nov 15, 2019·Medicine·Ji Hyun YunSung-Han Kim