PMID: 11604087Oct 18, 2001Paper

Impact of cancer predisposition and radiosensitivity on the population risk of radiation-induced cancers

Radiation Research
K Sankaranarayanan, R Chakraborty

Abstract

This paper provides a brief overview of the current evidence for cancer predisposition and for an increased sensitivity of individuals carrying such predisposing mutations to cancers induced by ionizing radiations. We also discuss the use of a Mendelian one-locus, two-allele autosomal dominant model for predicting the impact of cancer predisposition and increased radiosensitivity on the risk of radiation-induced cancers in the population and in relatives of affected individuals using breast cancer due to BRCA1 mutations as an example. The main conclusions are the following: (1) The relative risk ratio of the risks of radiation-induced cancer in a heterogeneous population which has subgroups of normal and cancer-predisposed individuals to the risks in a homogeneous population (i.e., one which does not have these subgroups) increases with increasing dose; however, the dose dependence of the RR decreases at higher doses because of the fact that at high doses, the radiation risk to a homogeneous population will already be high. (2) The attributable risk (the proportion of cancers attributable to increased cancer susceptibility and increased radiosensitivity) follows a similar pattern. (3) When the proportion of cancers due to the s...Continue Reading

References

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Citations

Jun 12, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A CarmichaelJ M Dixon
Feb 12, 2013·Journal of Radiation Research·Konstantinas Povilas ValuckasValerijus Ostapenko
Mar 3, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Maria MoschoviNeofytos Prodromou
Oct 6, 2015·Journal of Carcinogenesis·Meghana V KashyapJamboor K Vishwanatha
Oct 15, 2003·Oncogene·Munira A Kadhim
Jul 24, 2003·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·John B Little

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