Impact of Capicua on Pancreatic Cancer Progression.

Annals of Surgical Oncology
Shohei YoshiyaMasaki Mori

Abstract

The transcription factor capicua (CIC) regulates mammalian development and homeostasis. Growing evidence shows that CIC suppresses various human cancers by directly repressing the downstream cancer-related target genes. This study investigated the clinical and biologic significance of CIC expression in pancreatic cancer (PC). The study reviewed 132 patients with PC who underwent curative resection. The patients were divided into two groups according to CIC immunoreactivity score by immunohistochemistry, and the associations between CIC expression, clinicopathologic characteristics, and postoperative prognosis were investigated. Moreover, the influence of CIC expression on the malignant potential of PC cells was assessed with cell proliferation, motility assays, and use of quantitative real time-polymerase chain reaction and Western blot on the downstream target genes of CIC in knockdown experiments. The low-CIC expression group showed a higher proportion of lymphatic invasion (72.9% vs. 53.1%; p = 0.024), intrapancreatic neural invasion (94.1% vs. 81.3%; p = 0.021), and extrapancreatic plexus invasion (30.9% vs. 7.8%; p = 0.0006) than the high-CIC expression group as well as significantly worse overall survival (p = 0.0002) and...Continue Reading

References

Oct 14, 2010·Cellular Signalling·Maozhen TianWilliam P Schiemann
Apr 25, 2012·Journal of Cell Science·Gerardo JiménezZe'ev Paroush
Nov 22, 2016·Nature Genetics·Ross A OkimotoTrever G Bivona
Oct 7, 2017·Cancer Science·Miwa TanakaTakuro Nakamura
Dec 19, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eunjeong KimYoontae Lee
Mar 27, 2018·Cell Cycle·Lucía Simón-CarrascoMatthias Drosten
May 8, 2018·Molecular Cancer Therapeutics·Arthur WinerPaolo Mignatti
May 31, 2018·Cancer Research·Simon WeissmannKristian Helin
Jul 13, 2018·Breast Cancer Research : BCR·Mandy DumortierAnne Chotteau-Lelièvre
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 10, 2019·Nature Communications·Severa BundaKenneth Aldape
Mar 31, 2019·The Journal of Surgical Research·Daisuke ImaiYoshihiko Maehara
May 18, 2019·Neoplasia : an International Journal for Oncology Research·Youyi ChenMasakiyo Sakaguchi
Jul 22, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Shohei YoshiyaMasaki Mori
Jul 23, 2019·The Journal of Clinical Investigation·Ross A OkimotoTrever G Bivona
Feb 2, 2020·Nature Reviews. Gastroenterology & Hepatology·Louis BuscailPierre Cordelier
Feb 12, 2020·Cancer Cell International·Jeon-Soo LeeYoontae Lee
Apr 2, 2020·JCI Insight·Inah HwangJihye Paik

❮ Previous
Next ❯

Citations

Nov 25, 2020·Annals of Surgical Oncology·Shohei YoshiyaMasaki Mori

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.