Impact of cardiosynchronous brain pulsations on Monte Carlo calculated doses for synchrotron micro- and minibeam radiation therapy

Medical Physics
Francisco Manchado de SolaA M Lallena

Abstract

The purpose of this study was to assess the effects of brain movements induced by heartbeat on dose distributions in synchrotron micro- and minibeam radiation therapy and to develop a model to help guide decisions and planning for future clinical trials. The Monte Carlo code PENELOPE was used to simulate the irradiation of a human head phantom with a variety of micro- and minibeam arrays, with beams narrower than 100 μm and above 500 μm, respectively, and with radiation fields of 1 × 2 cm and 2 × 2 cm. The dose in the phantom due to these beams was calculated by superposing the dose profiles obtained for a single beam of 1 μm × 2 cm. A parameter δ, accounting for the total displacement of the brain during the irradiation and due to the cardiosynchronous pulsation, was used to quantify the impact on peak-to-valley dose ratios and the full width at half maximum. The difference between the maximum (at the phantom entrance) and the minimum (at the phantom exit) values of the peak-to-valley dose ratio reduces when the parameter δ increases. The full width at half maximum remains almost constant with depth for any δ value. Sudden changes in the two quantities are observed at the interfaces between the various tissues (brain, skull, a...Continue Reading

References

May 1, 1995·Medical Physics·O K HarlingR D Rogus
Nov 10, 1998·International Journal of Cancer. Journal International Du Cancer·J A LaissueD N Slatkin
Mar 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Robert D ZwickerMohammed Mohiuddin
Jun 24, 2005·Physics in Medicine and Biology·E Bräuer-KrischA Bravin
Apr 4, 2006·International Journal of Radiation Oncology, Biology, Physics·Raphaël SerducBoudewijn van der Sanden
Jun 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·F Avraham DilmanianDavid J Anschel
Jun 19, 2009·Journal of Synchrotron Radiation·Yolanda PrezadoAlberto Bravin
Dec 10, 2009·Medical Physics·Y PrezadoA Bravin
Jun 1, 2010·International Journal of Radiation Oncology, Biology, Physics·Jeffrey C CrosbiePeter A W Rogers
Jul 22, 2010·Physics in Medicine and Biology·I Martínez-RoviraY Prezado
Oct 12, 2010·International Journal of Radiation Oncology, Biology, Physics·Audrey BouchetRaphaël Serduc
Aug 24, 2011·Medical Physics·I Martínez-Rovira, Y Prezadoa
Jan 25, 2012·International Journal of Radiation Oncology, Biology, Physics·Pierre DemanJean-François Adam
Jun 5, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Audrey BouchetRaphaël Serduc
Jun 6, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Elke Bräuer-KrischBjarne Stugu

❮ Previous
Next ❯

Citations

Oct 26, 2018·The British Journal of Radiology·Juergen MeyerYolanda Prezado
Nov 7, 2019·Physics in Medicine and Biology·Stefan BartzschMoeava Tehei
Oct 11, 2020·International Journal of Radiation Oncology, Biology, Physics·Franziska TreibelStefan Bartzsch
Aug 27, 2019·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·P PellicioliE Bräuer-Krisch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.