Impact of Cardiovascular Disease on Clinical Characteristics and Outcomes of Coronavirus Disease 2019 (COVID-19)

Circulation Journal : Official Journal of the Japanese Circulation Society
Yangjing XieHong Zhang

Abstract

To investigate the effect of cardiovascular disease (CVD) on the global pandemic, coronavirus disease 2019 (COVID-19), we analyzed the cases of laboratory-confirmed COVID-19 patients in Wuhan.Methods and Results:Data were extracted from the medical records. SARS-CoV-2 RNA was confirmed by RT-PCR. A total of 33 (53.2%) of 62 cases with CVD, who had higher prevalence of severe COVID-19 compared with non-CVD patients (P=0.027). The median age of all patients was 66.0 (53.3, 73.0) years old. Coronary artery disease (11.3%) and hypertension (38.7%) were the common coexisting CVDs in COVID-19 patients. High-sensitivity cardiac troponin I (hs-cTnI), creatinine, high-density lipoprotein-cholesterol, interleukin-6, C-reactive protein, prothrombin time, and D-dimer levels in the severe COVID-19 with CVD group were higher than in the non-severe COVID-19 with CVD group (P<0.05). For all patients, chest computed tomography (CT) showed ground-glass opacity (66.1%), local (21.0%), bilateral (77.4%), and interstitial abnormalities (4.8%). In COVID-19 patients with CVD, 27 (81.8%) were cured and discharged. 6 (18.2%) remained in hospital, including 2 (3.2%) patients requiring intubation and mechanical ventilation. The hs-cTnI levels in the rema...Continue Reading

References

Jan 1, 1993·Advances in Experimental Medicine and Biology·L K AlexanderR S Baric
May 29, 2004·Trends in Pharmacological Sciences·Anthony J TurnerNigel M Hooper
Jun 18, 2014·Cardiovascular Research·Alberico Luigi CatapanoGiuseppe Danilo Norata
Sep 1, 2015·Journal of the American Society of Nephrology : JASN·Valentina Kon, MacRae F Linton
Dec 12, 2017·European Heart Journal·Christian M MadsenBørge G Nordestgaard
Jan 5, 2020·Clinical and Experimental Pharmacology & Physiology·Tawar QaradakhiAnthony Zulli
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 23, 2020·The Lancet. Respiratory Medicine·Zhe XuFu-Sheng Wang
Mar 7, 2020·Nature Reviews. Cardiology·Ying-Ying ZhengXiang Xie

❮ Previous
Next ❯

Citations

May 31, 2020·The Journal of Clinical Hypertension·Marijana TadicCarla Sala
Apr 16, 2020·Obesity·Ricardo J Jose, Ari Manuel
May 15, 2020·European Journal of Clinical Investigation·Wiktor SmykMarcin Krawczyk
Jul 7, 2020·The Journal of Clinical Hypertension·Marijana TadicGiuseppe Mancia
Jul 12, 2020·Journal of Cardiac Surgery·Ahmed M A ShafiAmer Harky
Jul 6, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Abderrahim OussalahJean-Louis Guéant
Jul 13, 2020·Echocardiography·Matteo CameliSerafina Valente
Jul 13, 2020·Echocardiography·Fabiola B SozziFrancesco Blasi
Jun 27, 2020·Diabetes/metabolism Research and Reviews·Yue ZhouYangang Wang
Sep 16, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Tu-Hsuan ChangLuan-Yin Chang
Jul 25, 2020·Journal of Medical Virology·Jieyun ZhuJunyu Lu
Nov 18, 2020·Journal of Thrombosis and Thrombolysis·Kensuke MatsushitaOlivier Morel
Feb 27, 2021·Medicina clínica·Chendi LiangGang Qin
Jun 11, 2021·Medicina Clínica·Chendi LiangGang Qin
Jul 15, 2021·Reviews in Medical Virology·Kun LiuWei Liu
Aug 3, 2021·Frontiers in Pharmacology·Guyi WangYanjun Zhong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.