PMID: 22330622Feb 15, 2012Paper

Impact of carotid artery stenting on plasma interleukin-6, tumor necrosis factor-α and C-reactive protein

International Angiology : a Journal of the International Union of Angiology
Z Y XiaL X Wang

Abstract

This study aimed to investigate the impact of carotid artery stenting (CAS) on plasma levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and C-reactive protein (CRP). The levels of CRP, IL-6, and TNF-α were measured in 61 patients before CAS, 1 h, 2 weeks, 1 month, 6 months, and 12 months after the stenting. The levels of CRP, IL-6 and TNF-α increased immediately after CAS (P<0.05 or <0.01). The levels of CRP, IL-6 and TNF-α in patients receiving two stents for multiple lesions or single diffusive lesions was also high than in patients receiving one stent for a single lesion (P<0.05 or <0.01). The levels of CRP, IL-6 and TNF-α in patients with restenosis (14/61, or 23%) were higher than in those without restenosis (P<0.05 or <0.01). CAS was associated with a significant increase in plasma CRP, IL-6 and TNF-α. The levels of these inflammatory factors in patients with post-CAS restenosis were higher than in those without restenosis.

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