PMID: 22555034May 5, 2012Paper

Impact of castration with or without alpha-tocopherol supplementation on the urethral sphincter of rats

International Braz J Urol : Official Journal of the Brazilian Society of Urology
Mirian KracochanskyMiriam Dambros

Abstract

To analyze the impact of low levels of testosterone induced by orchiectomy and the effect of alpha-tocopherol supplementation on oxidative stress in the urethral sphincter. Forty male Wistar rats weighing 250-300 g were divided into four groups with 10 each: Sham group; Orchiectomy group: bilateral orchiectomy; Orchiectomy-pre-Tocopherol group: bilateral orchiectomy preceded by alpha-tocopherol supplementation for four weeks; Orchiectomy-full-Tocopherol group: bilateral orchiectomy with alpha-tocopherol supplementation for four weeks preceding the procedure and for eight weeks afterwards. At the protocol end, animals were euthanized and had the sphincter analyzed stereologically focusing on collagen and muscle fibers percentage. Oxidative stress levels were determined using 8-epi-PGF2. The 8-epi-PGF2 levels were statistically higher (p < 0.0003) in the Orchiectomy group compared to others groups while Sham and Orchiectomy-full-Tocopherol groups presented statistically similar values (p = 0.52). Collagen volumetric densities were significantly lower in Sham and Orchiectomy-full-Tocopherol groups (p < 0.022). Sham group presented statistically greater muscle fiber percent. Castration caused oxidative stress in the urethral sphinc...Continue Reading

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Citations

Jan 1, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Yuji HottaKazunori Kimura
Nov 3, 2016·American Journal of Physiology. Renal Physiology·Chen-Li Cheng, William C de Groat
Jan 10, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Andy SunChun-Pin Chiang
Dec 20, 2012·Expert Review of Anticancer Therapy·Vincenzo De GiorgiPierangelo Geppetti
Apr 30, 2013·Advanced Materials·Damon A Wheeler, Jin Z Zhang
Nov 28, 2013·The Journal of Clinical Endocrinology and Metabolism·Dorian R A SwartsMarco Volante
Sep 6, 2014·Journal of Cytology·Modugumudi Ananta Satya NarayanaBobbidi Venkatesh Phaneendra

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