Impact of caveolin-1 expression on clinicopathological parameters in renal cell carcinoma

The Journal of Urology
Akio HoriguchiMasamichi Hayakawa

Abstract

Caveolin-1 is a major structural component of caveolae, which are plasma membrane microdomains implicated in the regulation of intracellular signaling pathways. Previous studies of the expression and function of caveolin-1 in cancer have shown controversial results, indicating that the physiological role of caveolin-1 varies according to cancer type. We evaluated caveolin-1 expression in renal cell carcinoma and investigated its association with pathological features and clinical outcome. Caveolin-1 expression was evaluated by immunohistochemistry using rabbit polyclonal antibody against caveolin-1 in 60 paraffin embedded primary renal cell carcinoma specimens and 6 metastatic renal cell carcinoma specimens. When more than 50% of all cancer cell cytoplasm stained, the tumor was considered caveolin-1 positive. Associations between caveolin-1 expression, and pathological features and clinical outcomes were analyzed. Of 60 primary tumors 16 (26.7%) and 5 of 6 metastatic tumors (83.3%) were immunoreactive in more than 50% of cancer cells and considered caveolin-1 positive. Although no significant associations between caveolin-1 expression, pathological stage (T stage) and distant metastasis at initial presentation were observed, si...Continue Reading

References

Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·A J KoleskeM P Lisanti
Oct 6, 1998·Annual Review of Biochemistry·R G Anderson
Mar 2, 1999·Biochemical and Biophysical Research Communications·C RacineJ Couet
Mar 10, 2001·The American Journal of Pathology·K WiechenU Schneider
Nov 17, 2001·Urology·P H RajjayabunJ K Mellon
Dec 18, 2001·The Journal of Urology·Badar M MianLouis L Pisters
Oct 29, 2002·British Journal of Cancer·M SuzuokiH Katoh
Jun 18, 2003·Urologic Oncology·Rafael CarrionMichael B Morgan

❮ Previous
Next ❯

Citations

Jul 20, 2006·Acta Neuropathologica·V BarresiG Barresi
Apr 2, 2008·Current Oncology Reports·Ila Tamaskar, Ming Zhou
Jun 9, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maria R Tosi, Vitaliano Tugnoli
Dec 14, 2011·BMC Urology·Sandra SteffensJürgen Serth
Nov 15, 2011·Annual Review of Pathology·Federica SotgiaMichael P Lisanti
Mar 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yi WangMichael Ohh
Feb 27, 2008·International Journal of Radiation Biology·Maria Shatz, Mordechai Liscovitch
Aug 21, 2007·Human Pathology·Guang YangTimothy C Thompson
Mar 25, 2008·Experimental and Molecular Pathology·Guang YangTimothy C Thompson
May 17, 2008·Cancer Letters·Elke BurgermeisterMatthias P A Ebert
May 17, 2006·The International Journal of Biochemistry & Cell Biology·Li JiaJianing Zhang
Sep 20, 2006·Expert Opinion on Therapeutic Targets·Kenneth L van Golen
Jul 22, 2006·Advances in Enzyme Regulation·Dana RavidMordechai Liscovitch
Mar 17, 2005·World Journal of Gastroenterology : WJG·Bo SongLei Sun
Feb 5, 2005·American Journal of Physiology. Cell Physiology·Terence M Williams, Michael P Lisanti
Jun 28, 2007·Cancer·Ila TamaskarMing Zhou
Feb 4, 2011·Brain Tumor Pathology·Valeria Barresi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.

Caveolins & Signal Transduction

Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.