Impact of change in bedtime variability on body composition and inflammation: secondary findings from the Go Red for Women Strategically Focused Research Network.

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Marie-Pierre St-OngeSanja Jelic

Abstract

Variability in daily sleep patterns is an emerging factor linked to metabolic syndrome. However, whether reducing bedtime variability improves markers of disease risk has not been tested. Here, we assessed whether body composition and inflammation were impacted by changes in bedtime variability over a 6-week period, during which, women were instructed to maintain healthy, habitual sleep (HS) patterns (one arm of a randomized trial). Data were available for 37 women (age 34.9 ± 12.4 years, BMI 24.7 ± 2.9 kg/m2, sleep duration 7.58 ± 0.49 h/night). Body composition and leukocyte platelet aggregates (LPA) were measured at baseline and endpoint using magnetic resonance imaging and flow cytometry, respectively. Sleep data were collected daily using wrist actigraphy. Change in bedtime variability was calculated as the difference in the standard deviation (SD) of bedtimes measured during the 2-week screening period and the 6-week intervention period. Results showed that women who reduced their bedtime variability (n = 29) during the intervention had reductions in total (P < 0.001) and subcutaneous adipose tissue (P < 0.001) relative to women who increased/maintained (n = 8) bedtime variability. Similar effects were observed for LPA le...Continue Reading

Associated Clinical Trials

Jul 18, 2016·Marie-Pierre St-Onge

References

Jul 28, 2004·The American Journal of Clinical Nutrition·Wei ShenStanley Heshka
Apr 9, 2005·The American Journal of Clinical Nutrition·Dympna GallagherTamara B Harris
Oct 9, 2015·Medicine·Daniele MinervinoRaffaele Landolfi
Nov 2, 2016·Circulation·Marie-Pierre St-OngeUNKNOWN American Heart Association Obesity, Behavior Change, Diabetes, and Nutrition Committees of the Council on Lifestyle and Card
Feb 6, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Sokha NhekJeffrey S Berger
Mar 8, 2017·Journal of Translational Medicine·Jonathan D NewmanJeffrey S Berger
Jun 21, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Christopher PapandreouJordi Salas-Salvadó
Jul 16, 2019·The Lancet. Diabetes & Endocrinology·Ian J NeelandUNKNOWN International Chair on Cardiometabolic Risk Working Group on Visceral Obesity
Oct 2, 2019·Frontiers in Cardiovascular Medicine·Héloïse LebasYacine Boulaftali

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Citations

Feb 24, 2021·Journal of the American Heart Association·Marie-Pierre St-OngeDhananjay Vaidya

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Methods Mentioned

BETA
flow cytometry

Clinical Trials Mentioned

NCT02835261

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