Impact of Changes in Serum Calcium Levels on In-Hospital Mortality

Medicina
Charat ThongprayoonStephen B Erickson

Abstract

Background and objectives: Calcium concentration is strictly regulated at both the cellular and systemic level, and changes in serum calcium levels can alter various physiological functions in various organs. This study aimed to assess the association between changes in calcium levels during hospitalization and mortality. Materials and Methods: We searched our patient database to identify all adult patients admitted to our hospital from January 1st, 2009 to December 31st, 2013. Patients with ≥2 serum calcium measurements during the hospitalization were included. The serum calcium changes during the hospitalization, defined as the absolute difference between the maximum and the minimum calcium levels, were categorized into five groups: 0-0.4, 0.5-0.9, 1.0-1.4, 1.5-1.9, and ≥2.0 mg/dL. Multivariable logistic regression was performed to assess the independent association between calcium changes and in-hospital mortality, using the change in calcium category of 0-0.4 mg/dL as the reference group. Results: Of 9868 patients included in analysis, 540 (5.4%) died during hospitalization. The in-hospital mortality progressively increased with higher calcium changes, from 3.4% in the group of 0-0.4 mg/dL to 14.5% in the group of ≥2.0 mg/d...Continue Reading

References

Oct 1, 1981·Clinical Endocrinology·P H BaylisD A Heath
Nov 1, 1994·Journal of Clinical Epidemiology·M CharlsonJ Gold
Jan 1, 1994·Annual Review of Medicine·J J Wysolmerski, A E Broadus
Nov 1, 1996·The Veterinary Clinics of North America. Small Animal Practice·J M KrugerK R Refsal
May 23, 1998·Clinical Cardiology·T SuzukiK Shimada
Aug 5, 1998·Lancet·D A Bushinsky, R D Monk
Sep 21, 2000·European Journal of Clinical Investigation·B MüllerR Ritz
Mar 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J R ZivinM J Ryan
Feb 15, 2005·The Journal of Emergency Medicine·Katrina Hurley, Doug Baggs
Apr 5, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Camelia G GarofeanuWilliam F Clark
Sep 1, 2005·The Journal of Clinical Endocrinology and Metabolism·Thomas P Jacobs, John P Bilezikian
Apr 17, 2007·The American Journal of the Medical Sciences·Asif S Kazmi, Barry M Wall
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Oct 13, 2009·Burns : Journal of the International Society for Burn Injuries·Barbara KohutMette M Berger
Jan 7, 2010·Chest·Kristen C Sihler, Lena M Napolitano
Sep 4, 2010·American Journal of Nephrology·Jessica E MillerKamyar Kalantar-Zadeh
Apr 7, 2011·Electrolyte & Blood Pressure : E & BP·Jong Hyeok Jeong, Eun Hui Bae
Aug 15, 2012·Nephron. Clinical Practice·Arif Khwaja
Dec 15, 2012·Aging Clinical and Experimental Research·Antonino CatalanoAntonino Lasco
Dec 18, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Areef IshaniAllan J Collins
Feb 26, 2015·Clinical Nutrition Research·Judith A Beto
Apr 7, 2017·IJC Heart & Vasculature·Gary TseBryan P Yan
Jul 8, 2017·Circulation Research·David A EisnerAndrew W Trafford
Jan 10, 2018·International Journal of Clinical Practice·Charat ThongprayoonStephen B Erickson
Jan 31, 2018·Endocrine Research·Wisit CheungpasitpornStephen B Erickson
May 14, 2019·Nephrology·Charat ThongprayoonStephen B Erickson
Dec 13, 2019·International Journal of Clinical Practice·Charat ThongprayoonKianoush B Kashani
Jan 8, 2020·Medicines·Charat ThongprayoonStephen B Erickson
Jan 9, 2020·Postgraduate Medical Journal·Charat ThongprayoonKianoush Kashani
Jan 26, 2020·BMJ Evidence-based Medicine·Charat ThongprayoonKianoush B Kashani
Feb 2, 2020·Hospital Practice·Wisit CheungpasitpornStephen B Erickson
Feb 18, 2020·Hospital Practice·Charat ThongprayoonKianoush B Kashani

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Oct 23, 2020·Postgraduate Medical Journal·Charat ThongprayoonKianoush Kashani

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