Impact of chemotherapeutic dose intensity and hematologic toxicity on first remission duration in dogs with lymphoma treated with a chemoradiotherapy protocol

Journal of Veterinary Internal Medicine
Andrew VaughanLaurel E Williams

Abstract

Dose intensity has proven to be critical in maximizing chemotherapeutic efficacy for numerous human cancers. To date, the impact of dose intensity and toxicity on first remission duration has not been thoroughly assessed in dogs with lymphoma. Dogs that receive maximal dose intensity will have prolonged first remission duration. Sixty-two dogs with lymphoma that were treated according to a standardized chemoradiotherapy regimen and achieved durable complete remissions were identified from the medical records database of North Carolina State University. Dosage reductions and treatment delays resulting from chemotherapy-related neutropenia were evaluated retrospectively, and each patient's actual summation dose intensity and frequency of myelotoxicity were calculated. Impact of dose intensity and frequency of neutropenia on first remission duration were evaluated by Cox proportional hazards regression. Development of grade III or IV neutropenia during chemotherapy was found to be associated with prolonged first remission duration (P < .01). Dose intensity did not have a significant impact on remission duration (P = .07). Results of this study suggest that dosage reductions and treatment delays instituted to avoid repeated neutrop...Continue Reading

Citations

Dec 17, 2010·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Brian D HusbandsJaime F Modiano
May 3, 2012·Veterinary and Comparative Oncology·J H BurtonD H Thamm
Jul 4, 2012·Veterinary and Comparative Oncology·L A WittenburgD L Gustafson
Nov 30, 2012·The Journal of Small Animal Practice·P RiveraH von Euler

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