Impact of chlorhexidine mouth rinse use on postextraction infection via nitric oxide pathway.

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Nurdan OzmericErdinc Devrim

Abstract

Nitric oxide (NO) has been linked to inflammatory reactions, tissue destruction, host defense, and wound healing in oral diseases. It is known that arginase enzyme controls the synthesis of NO through arginine depletion. This study evaluated the arginase-NO pathway alteration in response to tissue injury after dental extraction surgery and the effect of postoperative use of 0.2% chlorhexidine gluconate rinse (CHX). This study included 28 individuals who had impacted mandibular third molars. They were randomly divided into two groups. Group A was comprised of 13 individuals who used postoperative CHX (0.2%) rinse, while group B included 15 individuals who did not use postoperative CHX rinse. For each patient, periodontal inflammatory status was evaluated. Salivary and gingival tissue samples were obtained before and 1 h and 1 week after the surgery to determine the NO level and arginase activity using spectrophotometric methods. NO level of tissue samples displayed an insignificant decrease in both groups postoperatively. However, arginase activity of tissue samples was significantly higher in group B compared to group A 1 week after surgery (p <or= 0.01). There were no significant changes in salivary arginase activity and NO le...Continue Reading

References

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Aug 24, 2004·Current Pharmaceutical Design·Gian Mario Tiboni, Ettore Clementini

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Citations

Sep 14, 2010·Journal of Periodontology·Leyla OzerNurdan Ozmeric

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