Impact of Chromosomal Architecture on the Function and Evolution of Bacterial Genomes

Frontiers in Microbiology
Thøger J KroghChristoph Kaleta

Abstract

The bacterial nucleoid is highly condensed and forms compartment-like structures within the cell. Much attention has been devoted to investigating the dynamic topology and organization of the nucleoid. In contrast, the specific nucleoid organization, and the relationship between nucleoid structure and function is often neglected with regard to importance for adaption to changing environments and horizontal gene acquisition. In this review, we focus on the structure-function relationship in the bacterial nucleoid. We provide an overview of the fundamental properties that shape the chromosome as a structured yet dynamic macromolecule. These fundamental properties are then considered in the context of the living cell, with focus on how the informational flow affects the nucleoid structure, which in turn impacts on the genetic output. Subsequently, the dynamic living nucleoid will be discussed in the context of evolution. We will address how the acquisition of foreign DNA impacts nucleoid structure, and conversely, how nucleoid structure constrains the successful and sustainable chromosomal integration of novel DNA. Finally, we will discuss current challenges and directions of research in understanding the role of chromosomal archi...Continue Reading

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Citations

Nov 7, 2019·Current Genetics·Jessica R Kisner, Nathan J Kuwada
Jan 12, 2020·Nucleic Acids Research·Liang QinRemus T Dame
Aug 23, 2020·Biomolecules·Veronika VozárikováĽubomír Tomáška
Jun 15, 2019·International Journal of Molecular Sciences·Géraldine Farge, Maria Falkenberg
May 7, 2020·Frontiers in Microbiology·Joanna Hołówka, Jolanta Zakrzewska-Czerwińska
Mar 14, 2019·Frontiers in Microbiology·Gregory T MarczynskiPriya Patel
May 15, 2019·Journal of Molecular Biology·Travis J SandersThomas J Santangelo
Aug 11, 2020·Metabolic Engineering Communications·Julie E ChavesJoshua K Michener
Mar 30, 2021·Frontiers in Microbiology·Monika GlinkowskaLeise Riber
Jul 28, 2021·Nature Communications·Lorenzo OliviJohn van der Oost

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Methods Mentioned

BETA
X-ray
ChIP-seq

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