Impact of chronic hepatitis C on HIV-1 disease progression

HIV Clinical Trials
Juan Carlos MartínVincent Soriano

Abstract

Although there is clear evidence of an accelerated progression of liver fibrosis in HIV-positive patients with chronic hepatitis C virus (HCV) infection, it is unclear whether HCV infection may influence HIV-1 disease progression. We have analyzed the impact of HCV on CD4 counts and plasma HIV RNA in a large group of HIV-positive individuals. Epidemiological data, CD4 counts, and plasma HIV RNA values were recorded from 902 consecutive HIV-1-positive persons who attended our institution since 1998. HCV infection was documented (antibodies and/or HCV RNA) in 72% of the total study population. The higher rates were seen among intravenous drug users (97%) compared to other groups (17% in homosexual men, 23% in patients who acquired HIV heterosexually). In a cross-sectional analysis performed at the first trimester of 2000, the mean CD4 count was lower among HCV-positive than among HCV-negative individuals (518 +/- 282 cells/microL vs. 620 +/- 302 cells/microL; p <.001). The mean plasma HIV RNA was 11,188 +/- 55,301 copies/mL in HCV-positive persons versus 6,352 +/- 32,152 copies/mL in HCV-negative persons (p =.03). Undetectable plasma HIV RNA (<50 copies/mL) was recognized in 54% of HCV-positive persons versus 64% of HCV negative ...Continue Reading

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Citations

Oct 26, 2010·BMC Infectious Diseases·Marc-Arthur LokoUNKNOWN ANRS CO 13 HEPAVIH Study Group
Aug 7, 2008·Journal of Addictive Diseases·Jag H Khalsa, Frank Vocci
Oct 17, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M SantinF Gudiol
Jun 21, 2005·Luminescence : the Journal of Biological and Chemical Luminescence·Maite AlayM Antònia Busquets
Aug 26, 2006·Alcoholism, Clinical and Experimental Research·David NunesJeffrey H Samet
Jan 23, 2008·Current Medical Research and Opinion·Anthony S WierzbickiBarry S Peters
Jan 28, 2006·The Lancet Infectious Diseases·Kirsty EnglandMarie-Louise Newell
Jan 7, 2014·Journal of the International AIDS Society·Hinta MeijerinkReinout van Crevel
Jun 27, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nick WalshNick Crofts
Aug 28, 2007·The Pediatric Infectious Disease Journal·Dariela MicheloudUNKNOWN Spanish Group of Pediatric HIV Infection
Nov 7, 2007·The Pediatric Infectious Disease Journal·Dariela MicheloudUNKNOWN Spanish Group of Pediatric HIV Infection

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