Impact of chronic hyponatremia on neurocognitive and neuromuscular function

European Journal of Clinical Investigation
Julie RefardtWiebke Fenske

Abstract

Chronic hyponatremia is common and associated with increased morbidity and mortality. However, whether treatment improves outcome in patients without significant symptoms is unclear. We here assessed the therapeutic outcome on clinical symptoms, neurocognitive and neuromuscular function in patients with chronic non profound hyponatremia. Prospective case-control study in 19 patients from the University Hospital Würzburg with chronic non profound hyponatremia without clinically apparent symptoms. At baseline and after a 14-day treatment period of hyponatremia, patients were assessed by specific clinical symptoms questionnaire, neurocognitive and neuromuscular function was analysed by five attention tests and a gait test consisting of 3 steps "in tandem." The results were compared to a control group of healthy volunteers. Compared to healthy volunteers, patients with mild (n = 10, mean serum sodium 132 ± 1.2 mmol/L) and moderate hyponatremia (n = 9, mean 126 ± 3.3 mmol/L) performed significantly worse in the neurocognitive subtests alertness (P = 0.018), divided attention (P = 0.017) and go/no-go (P = 0.026). Performance in the neuromuscular subtests was also lower in the patient group without reaching significance. The extent of...Continue Reading

Associated Clinical Trials

Oct 19, 2020·Helbert Rondon

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Citations

Mar 13, 2020·Circulation Research·Joanna M Joly, José A Tallaj
Feb 6, 2020·Journal of the American Society of Nephrology : JASN·Julie RefardtMirjam Christ-Crain
Mar 28, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Api ChewcharatKianoush B Kashani
Feb 20, 2021·International Urology and Nephrology·Cihan HeybeliPinar Soysal
Sep 5, 2021·The Journal of Clinical Endocrinology and Metabolism·Laura PotassoMirjam Christ-Crain
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