Impact of chronic kidney disease and anemia on health-related quality of life and work productivity: analysis of multinational real-world data.

BMC Nephrology
Heleen van HaalenRebecca Moon

Abstract

Reductions in health-related quality of life (HRQoL) in patients with chronic kidney disease (CKD) are thought to be exacerbated by the low hemoglobin (Hb) levels that define anemia, a common complication of CKD. The current analysis evaluated the impact of anemia on HRQoL and work productivity in patients with non-dialysis dependent and dialysis-dependent CKD using real-world data. Data were collected in France, Germany, Italy, Spain, the UK, the USA and China in 2012-2018 in the Adelphi Real World Disease Specific Programme™ for CKD, a large, cross-sectional, survey of physicians and their patients. Patients completed three patient-reported outcomes (PRO) instruments: the EuroQol 5-Dimension 3-level (EQ-5D-3 L), the Kidney Disease Quality of Life (KDQOL-36) instrument and the Work Productivity and Activity Impairment questionnaire. PROs were assessed by CKD stage and Hb levels, and regression analyses were performed with CKD stage and Hb level as independent variables and PROs as outcome variables, while adjusting for age, sex, CKD stage, comorbidities and cardiovascular risk. Overall, 5276 patients participated in the survey, including 28% stage 4 and 36% dialysis patients. Patients with lower Hb levels more often reported p...Continue Reading

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Citations

Nov 21, 2020·Expert Review of Pharmacoeconomics & Outcomes Research·Hani HussienAdrian Covic
Feb 12, 2021·Journal of the American Society of Nephrology : JASN·Steven FishbanePablo E Pergola
Mar 11, 2021·Journal of the American Society of Nephrology : JASN·Mark Canney, Adeera Levin
Mar 11, 2021·Journal of the American Society of Nephrology : JASN·Feby SaviraElla Zomer

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Software Mentioned

Real World Disease Specific [UNK] DSP )
Stata
SPSS Data Collection Survey Reporter
Adelphi

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