Impact of chronic obstructive pulmonary disease on acute-phase outcome of myocardial infarction

The American Journal of Cardiology
Kohei WakabayashiRon Waksman

Abstract

Several reports have alluded to the adverse effect of chronic obstructive pulmonary disease (COPD) on long-term prognosis of patients with myocardial infarction (MI). Little information is available, however, regarding the effects of a decrease in cardiopulmonary reserve imposed by COPD on in-hospital outcome of acute MI. This study aimed to evaluate the impact of COPD on acute-phase outcome of patients with acute MI. From a cohort of 3,249 consecutive patients with ST-elevation MI who underwent primary or rescue percutaneous coronary intervention, 365 patients were identified as having coexistent COPD. Their clinical presentation and in-hospital outcome were compared to those of 2,884 patients without COPD. The primary end point was a composite of in-hospital death or cardiogenic shock on presentation. Patients with COPD were older (p <0.001), more often women (p <0.001), and smokers (p <0.001). They had higher prevalence of chronic renal insufficiency (p <0.001), systemic hypertension (p = 0.001), and diabetes mellitus (p = 0.01). Patients with COPD had higher rates of the composite end point of death or cardiogenic shock (p <0.0001). After multivariate analysis, COPD remained a strong independent predictor of the composite e...Continue Reading

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Citations

Dec 7, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Piera BoschettoClaudio Ceconi
Feb 14, 2014·International Journal of Chronic Obstructive Pulmonary Disease·Koichi NishimuraPaul W Jones
Jun 4, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Surya P Bhatt, Mark T Dransfield
Sep 7, 2013·Chest·Carlo NozzoliLeonardo M Fabbri
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Feb 6, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Jordan B StromRobert W Yeh
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Jan 1, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Xin HuangGregg W Stone
May 23, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Jesús Recio IglesiasJosé Manuel Varela Aguilar

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