Impact of cigarette smoking cessation on plasma α-klotho levels

Medicine
Yoko KamizonoShin-Ichiro Miura

Abstract

Smoking cessation reduces the risk of cardiovascular disease and improves clinical outcomes. We studied the effect of smoking cessation on plasma levels of α-klotho, which is an antiaging protein. We treated 28 smokers (male:female = 23:5, 46 ± 12 years) with varenicline (n = 14) or a transdermal nicotine patch (n = 14) as part of a 12-week smoking cessation program (the VN-SEESAW Study). Pulse rate, blood pressure, plasma levels of α-klotho, fibroblast growth factor (FGF)-19, FGF-21, hemoglobin (Hb), and expiratory carbon monoxide (CO) concentration were measured before and after the antismoking intervention. Smoking cessation significantly decreased pulse rate, α-klotho, Hb, and CO concentration, but not FGF-19 or FGF-21 in all subjects. On the contrary, body mass index significantly increased after the intervention. Changes in α-klotho levels (values at week 12 - values at week 0) were negatively associated with α-klotho levels at week 0 and positively associated with changes in Hb levels. In addition, the successful smoking cessation group (n = 21) showed significant reductions in pulse rate, systolic blood pressure, α-klotho, Hb, and CO concentration. In conclusion, smoking cessation significantly decreased serum levels of...Continue Reading

References

May 1, 1992·Journal of Hypertension·A GroppelliG Mancia
Apr 5, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazumasa YamagishiTakashi Shimamoto
Jan 6, 2005·American Journal of Epidemiology·Hiroyasu IsoUNKNOWN JACC Study Group
Jul 20, 2005·Circulation·Majid EzzatiAlan D Lopez
Aug 27, 2005·Science·Hiroshi KurosuMakoto Kuro-o
Dec 27, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Hirofumi YasueHisao Ogawa
Apr 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yasushi OgawaMakoto Kuro-o
Jul 14, 2007·The Journal of Biological Chemistry·Benjamin C LinLuc R Desnoyers
Feb 16, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Hitomi TsukaharaKeijiro Saku
Sep 3, 2011·Journal of the American Geriatrics Society·Richard D SembaLuigi Ferrucci
Jan 25, 2013·The New England Journal of Medicine·Prabhat JhaRichard Peto
Jan 15, 2014·The American Journal of Pathology·Sangeetha Vadakke MadathilDespina Sitara
Sep 24, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Paula BuendíaRafael Ramírez
Oct 17, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Kohei TakataKeijiro Saku
Aug 21, 2015·The Tohoku Journal of Experimental Medicine·Nursen KelesAytekin Oguz
Sep 19, 2015·Scientific Reports·Kaori NakanishiKeiko Yamauchi-Takihara
Nov 6, 2015·Circulation. Cardiovascular Genetics·Allan LinnebergLise Lotte N Husemoen
Aug 10, 2017·Medical Archives·Maja MalenicaAdlija Causevic

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Citations

Feb 5, 2021·The Journal of Applied Laboratory Medicine·Jean-Sébastien PaquetteMathieu Pelletier

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