Impact of cigarette smoking on response to interferon therapy in chronic hepatitis C Egyptian patients

World Journal of Gastroenterology : WJG
A El-ZayadiA Saeed

Abstract

Smoking may affect adversely the response rate to interferon-alpha. Our objective was to verify this issue among chronic hepatitis C patients. Over the year 1998, 138 chronic hepatitis C male Egyptian patients presenting to Cairo Liver Center, were divided on the basis of smoking habit into: group I which comprised 38 smoker patients (>30 cigarettes/d) and group II which included 84 non-smoker patients. Irregular and mild smokers (16 patients) were excluded. Non eligible patients for interferon-alpha therapy were excluded from the study and comprised 3/38 (normal ALT) in group I and 22/84 in group II (normal ALT, advanced cirrhosis and thrombocytopenia). Group I was randomly allocated into 2 sub-groups: group Ia comprised 18 patients who were subjected to therapeutic phlebotomy while sub-group Ib consisted of 17 patients who had no phlebotomy. In sub-group Ia, 3 patients with normal ALT after repeated phlebotomies were excluded from the study. Interferon-alpha 2b 3 MU/TIW was given for 6 mo to 15 patients in group Ia, 17 patients in group Ib and 62 patients in group II. Biochemical, virological end-of- treatment and sustained responses were evaluated. At the end of interferon-alpha treatment, ALT was normalized in 3/15 patients...Continue Reading

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Citations

Nov 4, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·H Patel, E J Heathcote
Nov 30, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ramón Bataller
Jan 15, 2015·Journal of Medical Virology·Ekram W Abd El-WahabHanan Z Shatat
Mar 10, 2012·The Korean Journal of Internal Medicine·Hwa Young SongKyung-Ah Kim
Mar 11, 2010·European Journal of Gastroenterology & Hepatology·José L Alonso-MartínezFernando Olaz-Preciado
Jul 19, 2012·Bulletin of the World Health Organization·Nathan FordPhilipp duCros
Mar 21, 2012·Immunology and Cell Biology·Niamh E Mangan, Ka Yee Fung
Nov 9, 2019·Journal of the American Association of Nurse Practitioners·Carol ReidNasim Salehi
Oct 13, 2006·World Journal of Gastroenterology : WJG·Abdel-Rahman El-Zayadi

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