Abstract
Impaired fibrinolysis is associated with thromboembolic complications in hypertensive patients. Cardiovascular morbidity/mortality rates have been reported high even after lowering the elevated blood pressure with antihypertensive drugs. We investigated the effects of clinically used dosages of cilazapril on the fibrinolytic system in hypertensive patients. The present study was performed among 30 hypertensive patients (22 women, eight men), who received 2.5-5.0 mg cilazapril daily for 1 month. Before and after the cilazapril treatment, patients' venous blood was drawn for fibrinolytic tests. The fibrinolytic activity was examined utilizing the euglobulin clot lysis time and fibrin plate methods. Using the fibrin plate method, as compared with the pretreatment group, we observed a 57% increased activity in the hypertensive patients receiving cilazapril (P < 0.001). When assessed by the euglobulin clot lysis time method, the activity due to cilazapril treatment was found to be relatively low, although highly significant (approximately 20%, P < 0.001). Changes in fibrinolytic activity were observed in 23 (77%) hypertensive patients after cilazapril treatment; however, their blood pressure remained normal. The remaining seven pati...Continue Reading
References
Jan 1, 1992·The Journal of Clinical Investigation·L BellS L Warren
Sep 3, 1992·The New England Journal of Medicine·K SwedbergH Wedel
Apr 2, 1992·The American Journal of Cardiology·H W Schnaper
Feb 1, 1991·American Journal of Hypertension·G Gleerup, K Winther
May 1, 1991·Circulation·A ZalewskiT D Bjornsson
Apr 1, 1991·Journal of Internal Medicine·J H JanssonT K Nilsson
Mar 31, 1990·Lancet·S MacMahonJ Stamler
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J A OlsonM K Raizada
Jun 1, 1991·The American Journal of Cardiology·S YusufC Furberg
Jul 5, 1990·The New England Journal of Medicine·J A PanzaS E Epstein
Nov 11, 1989·BMJ : British Medical Journal·P H HeldC D Furberg
Dec 1, 1989·European Heart Journal·K SakataA Takada
Dec 26, 1989·The American Journal of Medicine·C H KleinbloesemU W Wiegand
May 1, 1989·The American Journal of Physiology·J M PatelM K Raizada
Apr 1, 1974·Thrombosis Research·P M Mannucci
Feb 27, 1984·The American Journal of Medicine·W P Castelli
Mar 1, 1995·The Journal of Clinical Investigation·D E VaughanK Tong
Dec 1, 1994·American Heart Journal·L LindH Lithell
Jan 15, 1995·Annals of Internal Medicine·B L KasiskeT A Louis
Jun 1, 1993·Circulation·P M RidkerD E Vaughan
Mar 6, 1997·The American Journal of Cardiology·D E Vaughan
May 20, 1997·Circulation·C HeldB Wiman
Jan 25, 2000·Circulation·K A PoliD Levy