PMID: 9451426Feb 6, 1998Paper

Impact of clinical and morphological variables in classification and regression tree-based survival (CART) analysis of CML with special emphasis on dynamic features

European Journal of Haematology
J ThieleR Fischer

Abstract

To determine parameters of predictive value in CML, a retrospective clinico-pathological study was performed. This included laboratory data and (pretreatment) bone marrow biopsies of 120 patients with a monotherapy by busulfan (BU) and 50 patients with interferon-alpha 2b (IFN) treatment. Median survival in the BU group was 39 months and in the IFN-treated patients 65 months. Morphological features (CD61-positive megakaryocytes, argyrophilic fibres, pseudo-Gaucher cells) were evaluated by morphometry. Additionally, we measured the incidence of apoptosis (in situ end-labelling technique) and the expression of the proliferating cell nuclear antigen (PCNA). The ratio between the proliferative and apoptotic cell fraction was coined leukaemia turnover index (LTI). In order to estimate the impact of clinical and various morphological as well as dynamic features of prognostic significance, a multivariate analysis was carried out using the classification and regression tree approach (CART). Discrimination of single disease parameters revealed that fibrosis remained the most significant variable for survival in both therapeutic groups. Indicators of myeloid metaplasia such as occurrence of erythro-normoblasts and/or splenomegaly were im...Continue Reading

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Citations

Nov 7, 2003·Journal of Exposure Analysis and Environmental Epidemiology·A RoyP J Lioy
Jan 7, 2006·Leukemia & Lymphoma·Juergen Thiele, Hans M Kvasnicka
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H M KvasnickaH E Schaefer

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