Impact of clinical trials on the cost of cancer care

Medical Care
T N ChirikosJ P Krischer

Abstract

Empirical evidence on the economic impact of cancer clinical trials is in short supply, but it is widely assumed that clinical trials add at least 10% to overall costs. To estimate how much, if at all, trial enrollment increases the use of scarce resources in treating breast, lung, lymphoma, and ovarian cancer patients. A profile of the cumulative charges for all inpatient and outpatient hospital care received by a sample of patients over an observation period beginning at diagnosis and continuing for upwards of 44 months postdiagnosis. Patients are classified by whether they were enrolled on an IRB-sanctioned research protocol and, if so, by the type of protocol. Both univariate and multivariate statistical tests are conducted to appraise whether cumulative charges differ between patients who were enrolled on key types of protocols and those who were not. Approximately 1,900 breast, lung, lymphoma, and ovarian cancer patients treated at a single center. Clinical endpoints and demographic, disease, and therapy characteristics of patients that drive treatment costs. Controlling for demographic and disease characteristics, initial therapy, and key endpoints, the net effect of trial participation on cumulative charges for hospital...Continue Reading

Citations

Dec 2, 2004·Expert Opinion on Pharmacotherapy·Michel van AgthovenAnton Hagenbeek
Apr 15, 2015·Journal of the National Cancer Institute·Matthew C CheungUNKNOWN Committee on Economic Analysis and the Hematology Disease Site Committee, NCIC Clinical Trials Group
Apr 15, 2010·Journal of Psychosocial Oncology·Annemarie ConlonPatti Aldredge
Nov 19, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Blase N PoliteMichael T Halpern
Sep 26, 2003·Cancer·Wei DuWilliam P Peters
Feb 1, 2012·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Natalie Chun, Minjung Park
May 30, 2020·Hematological Oncology·Chloé HerledanCatherine Rioufol
Mar 22, 2002·Cancer Control : Journal of the Moffitt Cancer Center·Thomas N Chirikos
Feb 25, 2003·Cancer Control : Journal of the Moffitt Cancer Center·Thomas N Chirikos

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