Impact of clinical variables on Borrelia burgdorferi-specific antibody seropositivity in acute-phase sera from patients in North America with culture-confirmed early Lyme disease.

Clinical and Vaccine Immunology : CVI
Gary P WormserMaria E Aguero-Rosenfeld

Abstract

Erythema migrans, the most common manifestation of Lyme disease, has been associated with highly variable rates of seropositivity for antibodies to Borrelia burgdorferi. Differences in the sensitivities of serologic assays for the detection of these antibodies, however, may not be the only or even the primary explanation for this observation. We investigated the impacts of four clinical variables on seropositivity--the duration of erythema migrans, the presence of single versus multiple skin lesions, and the gender and age of the patient. In this analysis, three different serologic tests were performed on acute-phase sera from 175 untreated patients with culture-confirmed erythema migrans: the C6 single-peptide enzyme-linked immunosorbent assay (ELISA), a commercially available ELISA in which a whole-cell sonicate of B. burgdorferi was the antigen, and a two-tier procedure. Irrespective of the serologic test performed, the results showed that seropositivity rates increased with the duration of the erythema migrans for patients with single lesions (P < 0.001) but not for those with multiple skin lesions. The variability in seropositivity rates was greatest for the two-tier testing strategy, with a >6-fold-higher rate of seroposi...Continue Reading

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Citations

Jan 29, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C W AngT Herremans
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Dec 2, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Raphael B Stricker, Lorraine Johnson
May 28, 2020·BMJ : British Medical Journal·Bart Jan KullbergJoppe W Hovius
Apr 25, 2019·BMC Public Health·Allison DeLongHarriet Kotsoris
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Oct 23, 2020·Journal of Clinical Microbiology·Michael R MoselJohn N Aucott
Jan 29, 2021·Clinical Microbiology Reviews·John A Branda, Allen C Steere

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