Impact of Cognitive Reserve and Structural Connectivity on Cognitive Performance in Multiple Sclerosis

Frontiers in Neurology
Elisabet Lopez-SoleySara Llufriu

Abstract

Background: Cognitive reserve (CR) could attenuate the impact of the brain burden on the cognition in people with multiple sclerosis (PwMS). Objective: To explore the relationship between CR and structural brain connectivity and investigate their role on cognition in PwMS cognitively impaired (PwMS-CI) and cognitively preserved (PwMS-CP). Methods: In this study, 181 PwMS (71% female; 42.9 ± 10.0 years) were evaluated using the Cognitive Reserve Questionnaire (CRQ), Brief Repeatable Battery of Neuropsychological tests, and MRI. Brain lesion and gray matter volumes were quantified, as was the structural network connectivity. Patients were classified as PwMS-CI (z scores = -1.5 SD in at least two tests) or PwMS-CP. Linear and multiple regression analyses were run to evaluate the association of CRQ and structural connectivity with cognition in each group. Hedges's effect size was used to compute the strength of associations. Results: We found a very low association between CRQ scores and connectivity metrics in PwMS-CP, while in PwMS-CI, this relation was low to moderate. The multiple regression model, adjusted for age, gender, mood, lesion volume, and graph metrics (local and global efficiency, and transitivity), indicated that th...Continue Reading

References

Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Apr 25, 2006·Multiple Sclerosis : Clinical and Laboratory Research·J SepulcreP Villoslada
Nov 15, 2008·Lancet Neurology·Nancy D Chiaravalloti, John DeLuca
Jul 4, 2009·NeuroImage·Douglas N Greve, Bruce Fischl
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Sep 2, 2011·Human Brain Mapping·Marco BattagliniNicola De Stefano
Jan 9, 2013·Current Opinion in Neurobiology·Olaf Sporns
Apr 12, 2013·Neurology·Maria Pia AmatoNicola De Stefano
Jul 31, 2013·Multiple Sclerosis : Clinical and Laboratory Research·James F Sumowski, Victoria M Leavitt
Feb 6, 2014·Ageing Research Reviews·Ronald S PetraliaPamela J Yao
Feb 24, 2015·Nature Reviews. Neuroscience·Alex FornitoMichael Breakspear
Apr 30, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Claire M ModicaRalph Hb Benedict
May 1, 2015·Frontiers in Neurology·Menno M SchoonheimJeroen J G Geurts
Sep 17, 2015·PloS One·Eloy Martínez-HerasSara Llufriu
Nov 26, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jelle VeraartDmitry S Novikov
Apr 14, 2016·Journal of Neurology·Brian M SandroffJohn DeLuca
May 5, 2016·Human Brain Mapping·Paulo MarquesNuno Sousa
Jul 28, 2016·Annals of Neurology·UNKNOWN University of California, San Francisco MS-EPIC Team:Stephen L Hauser
Jan 5, 2017·NeuroImage. Clinical·Sara LlufriuAlbert Saiz
Feb 24, 2017·PLoS Computational Biology·Arno KleinAnisha Keshavan
Jan 6, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Maria Assunta RoccaMassimo Filippi
Feb 28, 2018·Brain and Behavior·Helene Højsgaard ChowFinn Sellebjerg
Apr 24, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Sara LlufriuMassimo Filippi
Aug 31, 2018·Nature Reviews. Neuroscience·Massimiliano Di FilippoPaolo Calabresi
Mar 11, 2019·Multiple Sclerosis and Related Disorders·Gabriella SantangeloLuigi Trojano
Aug 25, 2019·Human Brain Mapping·Tom A FuchsMichael G Dwyer
Dec 19, 2019·Neurology. Neuroimmunology and Neuroinflammation·Nuria Sola-VallsFrancesc Graus
Mar 18, 2020·Multiple Sclerosis and Related Disorders·Artemios ArtemiadisGeorgios Hadjigeorgiou

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Software Mentioned

Brain Connectivity Toolbox
MRtrix3
Mindboggle
SIENAX
FSL
FIRST
FreeSurfer
R
PwMS
Jim7

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