Impact of Colloidal Fluid on Stent Failure Under Extrinsic Ureteral Obstruction: An In Vitro Experimental Study.

Journal of Endourology
Yaniv ShiloBrian Berkowitz

Abstract

Background and Purpose: Drainage of an obstructed kidney due to extrinsic ureteral obstruction (EUO) is imperative. Ureteral stents, commonly employed to facilitate drainage, often fail under EUO; this is usually attributed to external pressure over the ureter that occludes the stent lumen. We showed previously that external pressure and deformation of the ureter, alone, cannot explain frequent stent failure and speculated that colloids present in urine may play a critical synergetic role. In this study, we evaluate the role of colloidal fluid in ureteral obstruction under extrinsic compression. Materials and Methods: An in vitro ureter-stent model was employed using a latex tube to simulate a flexible ureter connecting simulated glass kidney and bladder units. The ureter was placed in deformed configuration of 40° with external pressure of 2000 g exerted over the deformed region of the stented ureter, representing extrinsic pressure. Four different ureteral stents were tested-4.8F, 6F, 7F, and 8F. Colloidal solution based on chicken albumin was injected through the simulated kidney into the stented ureter. Four replicates were performed for each stent diameter and straight stented ureters with no external pressure were used as...Continue Reading

References

Jul 16, 1999·Journal of Endourology·A V BrewerR V Clayman
Aug 31, 2002·Urological Research·A-C Kinn, H Lykkeskov-Andersen
Jun 14, 2003·The Journal of Pharmacy and Pharmacology·Sean P GormanDavid S Jones
Apr 8, 2006·Urology·Kari HendlinManoj Monga
Nov 18, 2008·The Journal of Urology·Matthew S ChristmanBrian K Auge
Aug 29, 2009·BJU International·Matthew S ChristmanBrian K Auge
Dec 15, 2012·Journal of Endourology·Ammara AbbasiKenneth Ogan
Nov 15, 2019·Journal of Endourology·Miki HaiflerNir Kleinmann

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