Impact of comorbidities and use of common medications on cancer and non-cancer specific survival in esophageal carcinoma

BMC Cancer
Liru HeSteven H Lin

Abstract

Chronic comorbidities and some of the commonly-used medications are thought to affect cancer patients' outcomes, but their relative impact on esophageal carcinoma (EC) has not been well studied. The purpose of the study was to identify the chronic comorbidities and/or commonly-used medications that impact EC patient survival. A total of 1174 EC patients treated with chemoradiotherapy (CRT) with or without surgery in one institution from 1998 to 2012 were retrospectively included. Seven kinds of frequently occurring chronic comorbidities and 18 types of regularly-taken medications were obtained from medical records. Since it is expected prognostic factors have different effects between surgery patients and non-surgery patients, the impact value of all variables and the corresponding interactions with surgery on survival were evaluated in Cox proportional hazards regression model. Overall mortality, EC-specific mortality and non EC-specific mortality were endpoints. We found that atrial fibrillation was the only comorbidity that showed a significant impact on non-EC specific survival for all patients (HR 1.72, P = 0.03), whereas hypothyroidism was the only comorbidity that was evaluated as an independent predictive factor for ove...Continue Reading

References

Jul 11, 2002·The Lancet Oncology·David Garfield
Feb 26, 2004·Journal of Vascular Nursing : Official Publication of the Society for Peripheral Vascular Nursing·Gail Ann DeLuca Havens
May 27, 2004·JAMA : the Journal of the American Medical Association·Jay F PiccirilloEdward L Spitznagel
Feb 21, 2006·World Journal of Gastroenterology : WJG·Jian-Yang MaJun-Jie Yang
Oct 18, 2006·Archives of Otolaryngology--head & Neck Surgery·Marc NelsonMarshall Strome
May 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shahram SadeghiUNKNOWN Australian Cancer Study
Jul 31, 2009·PloS One·Olaia Martínez-IglesiasAna Aranda
Jul 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sumanta Kumar Pal, Arti Hurria
Aug 7, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Aleck H HercbergsDavid Garfield
Oct 22, 2011·The Journal of Thoracic and Cardiovascular Surgery·Miral R SadariaMichael J Weyant
Aug 29, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin S ChoeStanley L Liauw
Sep 7, 2012·Acta Oncologica·Heath D SkinnerThomas M Guerrero
Jan 16, 2013·Endocrine-related Cancer·Lars C Moeller, Dagmar Führer
Aug 9, 2013·International Journal of Molecular Sciences·Adam R BrownFrank A Simmen
Nov 6, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Oriana YuLaurent Azoulay
May 7, 2014·Gastroenterology·Theresa NguyenHashem B El-Serag

❮ Previous
Next ❯

Citations

Oct 6, 2017·Science Translational Medicine·Matthias Pinter, Rakesh K Jain
Sep 26, 2017·Journal of Managed Care & Specialty Pharmacy·Chrisanne WilksRobert Dubois
Feb 7, 2018·Journal of Managed Care & Specialty Pharmacy·Chrisanne WilksRobert Dubois
Jun 10, 2016·Clinical Medicine Insights. Gastroenterology·Vishnu Prasad Nelamangala RamakrishnaiahSunu Cyriac

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.