Impact of comorbidities on fatigue in rheumatoid arthritis patients: Results from a nurse-led program for comorbidities management (COMEDRA)

Joint, Bone, Spine : Revue Du Rhumatisme
Anne TournadreMaxime Dougados

Abstract

To analyze the factors associated with fatigue focusing on comorbidities in a large cohort of rheumatoid arthritis (RA). Cross-sectional analyses were performed on RA patients from the French COMEDRA cohort study, a nurse-led program for comorbidities management. Fatigue was assessed using Question 3 of the Rheumatoid Arthritis Impact of Disease (RAID) score on a 0-10 numerical rating scale (NRS). Fatigue was defined as acceptable if ≤ 2, moderate if 3 or 4, or severe if ≥ 5 out of 10. Using univariate and multivariate models, the relationship between fatigue and demographics, social, disease characteristics, comorbidities (cardiovascular, infections, cancer, pulmonary, osteoporosis, and psychiatric disorders), physical activity, quality of life, and treatments was investigated. In total, 962 patients were analyzed. The mean fatigue score was 3.8 ± 2.7, 40% of patients reported severe fatigue. Patients had an average of 1.8 additional morbid conditions, with anxiety/depression the most common (52%). In univariate analysis, severe fatigue was more frequent in women, in patients not working, and in those with less physical activity. It was associated with disease duration and activity, mHAQ, pain, sleeping and emotional difficult...Continue Reading

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Citations

May 10, 2020·RMD Open·Janet E Pope
Aug 28, 2020·Arthritis & Rheumatology·Melissa HoldrenUNKNOWN Canadian Early Arthritis Cohort investigators
Oct 3, 2021·Nature Reviews. Rheumatology·Kristen DaviesWan-Fai Ng
Nov 11, 2021·ACR Open Rheumatology·Susanne PetterssonChristina H Opava
May 7, 2020·Joint, Bone, Spine : Revue Du Rhumatisme·Chia-Wen HsuMing-Chi Lu

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