Impact of Concomitant Endometriosis on Phenotype and Natural History of Inflammatory Bowel Disease

Inflammatory Bowel Diseases
Kristen K LeeJean-Frederic Colombel

Abstract

Inflammatory bowel disease (IBD) and endometriosis are immune-mediated chronic inflammatory disorders affecting young women. The clinical significance of concomitant endometriosis on the course of IBD has not been previously studied. The aim of this study was to determine whether women with concomitant endometriosis and IBD have a unique phenotype and worse prognosis of IBD. This was a case-control study performed at a tertiary referral center. Cases were women with diagnoses of both endometriosis and IBD. Two random IBD controls without endometriosis were selected for each case, frequency matched for age and IBD type, Crohn's disease (CD) or ulcerative colitis. Primary outcomes included disease phenotype; the use of immunomodulators, antiTNF agents, or combination therapy and the need for IBD-related surgery. We identified 51 cases with endometriosis and IBD (28 CD, 23 ulcerative colitis). There was no difference in race, age at IBD diagnosis, and mean duration of IBD between endometriosis-IBD cases and controls. Among endometriosis-CD patients whose endometriosis was surgically verified, there was a higher risk for stricturing disease compared with CD controls (odds ratio, 11.8; 95% confidence interval, 2.03-69.0). There was ...Continue Reading

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Citations

Oct 19, 2016·Inflammatory Bowel Diseases·Louise E GloverMary Wingfield
Sep 4, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M G PorporaP L Benedetti Panici
Jul 2, 2019·Human Reproduction Update·Nina ShigesiChristian M Becker
Mar 9, 2020·Journal of Neuroinflammation·Yajing WeiShuzhong Yao
Jun 2, 2018·Case Reports in Gastrointestinal Medicine·S CasiraghiM Ronconi
Jul 7, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Francesca ChiaffarinoPaolo Vercellini

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