Impact of congenital or experimental hypogonadotrophism on the radiation sensitivity of the mouse ovary

Human Reproduction
R G GosdenM J Faddy

Abstract

As the numbers of young people making a full recovery from haematological malignancy continue to rise, reproductive science must investigate ways of ameliorating the sterilizing effects of high-dose chemotherapy and total body irradiation. Because there is conflicting evidence as to whether lower serum gonadotrophin concentrations have any protective effect on the gonads, a study was designed to test whether either congenital or experimentally induced hypogonadism reduces the radiosensitivity of the mouse ovary. Test subjects were either homozygous for the hpg locus or animals of normal phenotype treated with a gonadotrophin-releasing hormone antagonist. At 14 days after receiving a single dose of 0.1, 0.2 or 0.3 Gy X-rays or a sham procedure, primordial follicles in the ovaries of the two experimental groups and controls were counted in serial histological sections. The doses at which half of the follicles were lost (LD50) were estimated as 0.11 +/- 0.02, 0.19 +/- 0.02 and 0.17 +/- 0.02 Gy respectively. There was no significant difference between the controls and the antagonist-treated animals, but the congenitally hypogonadal group was unexpectedly more sensitive to radiation. Either way, these results do not support the hypo...Continue Reading

Citations

Dec 28, 2010·Journal de gynécologie, obstétrique et biologie de la reproduction·S Bringer-DeutschA Delvigne
Jul 27, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A B ThomsonW H B Wallace
Feb 16, 2005·Current Opinion in Obstetrics & Gynecology·Tommaso Falcone, Mohamed A Bedaiwy
Dec 21, 2006·Obstetrical & Gynecological Survey·Enbal Marhhom, Ilan Cohen
Nov 5, 2010·Clinical Obstetrics and Gynecology·S Samuel KimBrian Petroff
May 27, 2010·Journal of Pediatric Hematology/oncology·Kenny A Rodriguez-Wallberg, Kutluk Oktay
Jun 3, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Marvin L Meistrich, Gunapala Shetty
Jul 19, 2006·Asian Journal of Andrology·Theodoros MaltarisRalf Dittrich
May 7, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·M MyersJ B Kerr
Mar 31, 2012·ISRN Obstetrics and Gynecology·Chung-Hoon Kim, Gyun-Ho Jeon
May 1, 2006·Women's Health·Mohamed A Bedaiwy, Tommaso Falcone
Jul 27, 2007·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·J K W Yap, M Davies
Mar 17, 2007·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A Imai, T Furui
Nov 15, 2011·Cancer Treatment Reviews·Kenny A Rodriguez-Wallberg, Kutluk Oktay
Aug 3, 2010·Journal de gynécologie, obstétrique et biologie de la reproduction·C BasilleR Fanchin
May 16, 2009·Mutation Research·N CamatsM Garcia Caldés
Oct 4, 2005·British Journal of Haematology·Mark F H Brougham, W H B Wallace
Apr 3, 2009·Pediatric Blood & Cancer·Kenny A Rodriguez-Macias WallbergOuti Hovatta
Mar 21, 2009·Pediatric Blood & Cancer·Erin R WestTeresa K Woodruff
Jun 11, 2009·Pediatric Blood & Cancer·Robert J Johnston, W Hamish B Wallace
Mar 8, 2014·CA: a Cancer Journal for Clinicians·Jonathan D KortLynn M Westphal
Sep 19, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Theodoros MaltarisRalf Dittrich
Sep 17, 2011·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Sofia BouchlariotouJosef Neulen
Jun 18, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·Angela B ThomsonW Hamish B Wallace
Jun 17, 2016·Human Fertility : Journal of the British Fertility Society·Alexander Tuan FalkNicolas Magné
Sep 25, 2008·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Nicole N Zakak
May 12, 2011·Reproduction, Fertility, and Development·D J Handelsman
Jan 1, 2009·Expert Review of Endocrinology & Metabolism·Theodoros MaltarisRalf Dittrich
Oct 31, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Murat Sönmezer, Kutluk Oktay
Feb 7, 2001·Current Opinion in Obstetrics & Gynecology·J DonnezM Nisolle
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Elisabeth C LarsenAnders Nyboe Andersen
Apr 27, 2000·Endocrine Reviews·E A McGee, A J Hsueh
Jan 14, 2011·Annals of Medicine·Jacques DonnezMarie-Madeleine Dolmans
Sep 23, 2003·Current Opinion in Obstetrics & Gynecology·Zeev Blumenfeld
Sep 19, 2019·Oxidative Medicine and Cellular Longevity·Yasmen F MahranHind N Alotaibi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.