Impact of conventional anesthesia on auditory brainstem responses in mice

Hearing Research
Marjolein A J van LooijBert G A van Zanten

Abstract

Anesthesia is known to affect the auditory brainstem response (ABR) in animals often used in hearing research. This study describes the differences in ABRs between awake and anesthetized FVB/N mice. Intracranial electrodes connected to a head fixation pedestal were used for click-evoked ABR recordings. This pedestal served to immobilize mice, either awake or under anesthesia, in a 'free' sound field. The presence of myogenic noise in the awake condition obviously increases recording time. However it is demonstrated that recording times can be significantly reduced by increasing the stimulus repetition rate from 23 up to 80 impulses per second. This causes only a small but significant increase in absolute peak latencies in the awake condition, but has no significant effect on the overall ABR-waveform, nor on the ABR-threshold, nor on the ABR interpeak latencies, nor on the absolute peak latencies in the anesthetized condition. Anesthesia with ketamine/xylazine caused a significant prolongation of ABR-peak latencies and interpeak latencies as well as a significant upward shift (8.0+/-1.8 dB) of ABR-thresholds as compared to the awake condition. Under anesthesia the measurement accuracy of peak latencies, interpeak latencies and t...Continue Reading

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Citations

Jul 17, 2013·Journal of Neuroscience Methods·Kathleen J Maheras, Alexander Gow
Sep 18, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J P LimaE Schochat
Apr 15, 2009·Journal of the Association for Research in Otolaryngology : JARO·Martijn J H AgterbergSjaak F L Klis
Jan 20, 2012·Mechanisms of Ageing and Development·Marcella SpoorJ Gerard G Borst
Dec 3, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·David A BorkholderRobert D Frisina
Dec 21, 2018·PloS One·Atsuko T Maruyama, Shoji Komai
Oct 20, 2010·Somatosensory & Motor Research·Cornelius SchwarzChristian Waiblinger
May 23, 2019·Journal of Neurophysiology·Richard A FelixChristine V Portfors
Sep 15, 2019·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·JoAnn McGeeEdward J Walsh
Apr 30, 2015·Brain Structure & Function·Fei Gao, Albert S Berrebi
Jun 4, 2019·Frontiers in Neuroscience·Achim SchillingHolger Schulze

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