Impact of corticosteroid on intestinal injury in a gastroschisis rat model: morphometric analysis

Journal of Pediatric Surgery
Daniel BittencourtLourenço Sbragia

Abstract

The goal in the treatment of gastroschisis is to prevent intestinal injury. Corticosteroids are known by their effects at the inflammatory response and by the improvement on the intestinal maturity. The authors evaluated the effects of maternal corticosteroid administration on the intestines of rats that underwent fetal gastroschisis. A Correia-Pinto-modified gastroschisis rat model was used. Two groups were assessed: the control group (group 1) and the dexamethasone group (group 2). Each group was composed of control and sham fetuses, and fetuses with gastroschisis. Fetal body weight, intestinal weight, intestinal length, and protein were assessed. Histologic analysis involved measures of intestinal loop diameter, total intestinal wall, mucosa and submucosa, both circular and longitudinal muscle layers, and serosal thicknesses. Differences between groups and subgroups were tested by the analysis of variance method with a significant P value less than .05. Dexamethasone decreased in all the morphometric data except in the intestinal length. Dexamethasone increased the intestinal protein content in fetuses with gastroschisis, and control and sham fetuses. In both groups, all histologic parameters were increased in fetuses with g...Continue Reading

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Citations

Jun 20, 2007·Pediatric Surgery International·L Cara Jager, Hugo A Heij
May 29, 2010·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Jessico M LeitãoLourenço Sbragia
Nov 10, 2015·Journal of Pediatric Surgery·Christina FengDario O Fauza
Sep 20, 2007·International Journal of Experimental Pathology·Paulo Roberto Veiga QuemeloLuiz Cesar Peres
Jul 26, 2006·Journal of Pediatric Surgery·Mustafa Olguner, Feza M Akgür
Jun 4, 2014·Journal of Pediatric Surgery·Helen CarnaghanSimon Eaton
Nov 12, 2016·Journal of Pediatric Surgery·Christina FengDario O Fauza
Mar 22, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G H CallejasL Sbragia
May 14, 2020·Prenatal Diagnosis·Helen CarnaghanUNKNOWN Gastroschisis Study Group
Oct 29, 2020·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Ana P Cuzziol BoccioniRafael C Lajmanovich

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