Impact of cyclosporin treatment on health-related quality of life of patients with alopecia areata.

The Journal of Dermatological Treatment
Vivien Wai Yun LaiRodney Sinclair

Abstract

Alopecia areata (AA) is a disfiguring disease with substantial psychological burden. No studies explore the efficacy of pharmacotherapy through health-related quality of life (HRQoL) using both disease-specific and generic quality of life (QoL) instruments. We present the first study to elicit health utility from patients with AA and to evaluate the efficacy of cyclosporin in relation to HRQoL using both measures. Participants with moderate to severe AA from a placebo-controlled randomized trial investigating cyclosporin were administered the generic preference-based HRQoL instrument, Assessment of Quality of Life-8D (AQoL-8D) and the disease-specific HRQoL instrument, Alopecia Areata Symptom Impact Scale (AASIS). HRQoL was measured at each study visit and compared to baseline. A number of 32 participants were analyzed. The mean health utility was 0.748. At 3 months, the cyclosporin group had trends for greater improvement in HRQoL across 6 of 8 AQoL-8D dimensions and 5 of 7 AASIS symptom domains compared to placebo. HRQoL was lower than Australian population norms across 6 of 8 AQoL-8D dimensions. Patients with AA had a mean health utility of 0.748. Treatment with cyclosporin 4 mg/kg/d for 3 months resulted in trends for impro...Continue Reading

References

May 1, 1991·Comprehensive Psychiatry·E A ColónM K Hordinsky
Mar 25, 1999·Clinics in Dermatology·G C BodekerC K Ong
Jun 6, 2003·International Journal of Dermatology·Sergio Ruiz-DobladoMaria Jose García-Hernández
Apr 16, 2004·The Journal of Investigative Dermatology. Symposium Proceedings·Suephy C ChenMary K Goldstein
Aug 20, 2010·The Journal of Investigative Dermatology·Magali DuboisUNKNOWN Quality of Life Group of the French Society of Dermatology
Dec 12, 2013·The Journal of Investigative Dermatology. Symposium Proceedings·Qiuling ShiTito R Mendoza
Dec 12, 2013·The Journal of Investigative Dermatology. Symposium Proceedings·Tito R MendozaMadeleine Duvic
Apr 11, 2014·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Jeff RichardsonMunir A Khan
Feb 26, 2016·The British Journal of Dermatology·F RenczV Brodszky
Jun 28, 2016·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Aimee MaxwellJeff Richardson
Sep 8, 2018·The Australasian Journal of Dermatology·Vivien Wai Yun LaiRodney Sinclair
Nov 10, 2018·The Australasian Journal of Dermatology·William C CranwellRodney Sinclair
May 3, 2019·Journal of the American Academy of Dermatology·Vivien Wai Yun LaiRodney Sinclair

❮ Previous
Next ❯

Citations

Aug 12, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·Vivien Wai Yun Lai, Rodney Sinclair
Mar 11, 2021·JAMA Dermatology·Carolyn Goh
May 12, 2021·Clinics in Dermatology·Nicole FaganDmitri Wall
May 20, 2021·International Journal of Dermatology·Vivien Wai Yun LaiRodney Sinclair
Jul 24, 2021·Patient Preference and Adherence·Kunlawat Thadanipon, Poonkiat Suchonwanit
Feb 9, 2021·The Journal of Dermatological Treatment·Husein Husein-ElAhmed, Martin Steinhoff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.