Impact of cytomegalovirus on early immunosenescence of CD8+ T lymphocytes after solid organ transplantation

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Sara CantisánR Solana

Abstract

The increasing number of elderly people eligible for solid organ transplants has made it necessary to reevaluate how the decline in immune function associated to ageing (immunosenescence) affects solid organ transplants. Some immunosenescence biomarkers, such as the expansion of CD28(-)CD8+ T lymphocytes, have been associated to cytomegalovirus infection and are related to a form of accelerated immune senescence in transplant recipients. However, the impact of cytomegalovirus replication on downregulation of CD28 on total CD8+ T cells is independent of patients' age, whereas downregulation on cytomegalovirus-specific CD8+ T cells depends on patients' age, inducing early immunosenescence of cytomegalovirus-specific CD8+ T cells in young but not elderly solid organ transplants recipients. Although immunosenescence in transplant recipients should be considered a two-edged sword as it is a risk factor for the development of tumors after transplantation, it has a beneficial effect in attenuating acute allograft rejection and correlates with better clinical outcomes.

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Citations

Nov 2, 2012·Immunity & Ageing : I & a·Rafael SolanaGraham Pawelec
Oct 9, 2014·Immunological Investigations·Orla MaguireHans Minderman
Jan 13, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David GoldeckEvelyna Derhovanessian
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Jul 1, 2017·International Journal of Molecular Sciences·Fakhri HassounehRafael Solana
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May 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen J GriffithsArne N Akbar
Dec 6, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Oscar Salvador Barrera-Vázquez, Juan Carlos Gomez-Verjan

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