Impact of DAT-SPECT on Management of Patients Suspected of Parkinsonism

Clinical Nuclear Medicine
Sahar MirpourRathan M Subramaniam

Abstract

To evaluate the value of I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (I-FP-CIT) dopamine transporter single photon emission computed tomography (DAT-SPECT) to change management strategies of patients suspected of parkinsonism. This was an institutional review board-approved, retrospective study. DAT-SPECT scans ordered by movement disorder specialist and neurologists from 2011-2014 were reviewed. Clinical data and radiological reports of 173 patients suspected of parkinsonism were reviewed. The DAT-SPECT scan results were correlated with clinical assessment and treatment changes. A total of 173 patients (104 male and 69 female subjects; age, 64.4 ± 12.6 years) suspected of parkinsonism were included. Median duration of symptoms was 36 months (range, 1-480 months). Scans were most often requested when there was diagnostic uncertainty in clinical features (59.6%, 103/173) or to differentiate one other disease from parkinsonism such as Parkinson disease (PD) versus essential tremor (23.7%, 41/173), PD versus drug-induced parkinsonism (8.7%, 15/173), or PD versus psychogenic (6.4%, 11/173) or vascular (1.7%, 3/173) disorders. Patients were classified, according to the DAT-SPECT scanning results, as those with ...Continue Reading

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Citations

Aug 31, 2019·The Journal of Neuropsychiatry and Clinical Neurosciences·Marine Ambar AkkaouiBéatrice Garcin
Jul 16, 2019·Clinical Nuclear Medicine·Chanwoo KimIl Ki Hong
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Nov 28, 2019·Deutsches Ärzteblatt International·Ralph BuchertJürgen Gallinat
Jun 12, 2019·Journal of Nuclear Medicine Technology·Norikazu MatsutomoEisuke Sato

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