Abstract
The impact of early peripheral blood chimerism on the outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is unclear. We aimed to determine whether day 14 peripheral blood chimerism after allo-HSCT predicts outcomes in patients with non-malignant diseases. Data from 56 patients who received allo-HSCT between April 2007 and March 2016 were retrospectively analyzed. Chimerism was evaluated using short-tandem repeat polymerase chain reaction, with mixed chimerism (MC) defined as greater than 1% recipient cells which was further categorized into low-level MC (> 1% and < 15% of recipient-derived cells) and high-level MC (≥ 15% of the recipient-derived cells). Thirty-six patients showed complete donor chimerism (CC), 14 low-level MC, and 6 high-level MC at day 14 post-transplant. The estimated 5-year event-free survival (EFS) was higher in the CC or low-level MC groups than in the high-level MC group (86.1% vs. 71.4% vs. 33.3%; P = 0.001). In BM or peripheral blood stem cell (BM/PBSC) transplants, the 5-year EFS was higher in the CC or low-level MC group than in the high-level MC group (93.1% vs. 66.7% vs. 0%; P < 0.001). However, in cord blood transplants, the 5-year OS and EFS according to the day 14 periphera...Continue Reading
References
Apr 16, 1998·Bone Marrow Transplantation·P BaderT Klingebiel
Oct 24, 2001·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·J H AntinD Weisdorf
Mar 22, 2003·Blood·Jose A Perez-SimonJesus F San Miguel
Dec 3, 2003·Bone Marrow Transplantation·W HoelleP Bader
Jun 4, 2004·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Christian Thiede
Mar 18, 2005·Leukemia·F BaronS Heimfeld
Mar 15, 2006·Transplantation·Olle RingdénGunilla Malm
Feb 21, 2007·Bone Marrow Transplantation·O RingdénJ Mattsson
Apr 9, 2008·Bone Marrow Transplantation·E OzyurekB N Horn
Feb 3, 2009·British Journal of Haematology·Mark LawlerUNKNOWN Severe Aplastic Anaemia Working Party of the European Blood and Marrow Transplant Group
May 8, 2009·Bone Marrow Transplantation·P SvenbergM Uzunel
Mar 23, 2010·Bone Marrow Transplantation·D M MickelsonE A Copelan
Sep 22, 2010·Blood·Rebecca A MarshAlexandra H Filipovich
Feb 18, 2011·Journal of Pediatric Hematology/oncology·Marta Gonzalez-Vicent, Miguel Angel Diaz
Sep 20, 2011·Leukemia·S BreuerS Matthes-Martin
Jan 20, 2012·The Korean Journal of Hematology·Meerim ParkHo Joon Im
Dec 4, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Suhag H ParikhPaul Szabolcs
Jan 15, 2014·Bone Marrow Transplantation·T G KetterlW Miller
Jun 19, 2014·Pediatric Blood & Cancer·Benjamin R OshrineNancy Bunin
Apr 14, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Rebecca A MarshStella M Davies
Aug 21, 2015·Pediatric Transplantation·Karin MellgrenJacek Winiarski
Feb 11, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Orly R KleinHeather J Symons
Jun 1, 2016·The Journal of Allergy and Clinical Immunology·Kanchan RaoPersis Amrolia
Nov 1, 2016·Pediatric Hematology and Oncology·Alberto MussettiFarid Boulad