Impact of dendritic spine preservation in medium spiny neurons on dopamine graft efficacy and the expression of dyskinesias in parkinsonian rats.

The European Journal of Neuroscience
Katherine E SoderstromKathy Steece-Collier

Abstract

Dopamine deficiency associated with Parkinson's disease (PD) results in numerous changes in striatal transmitter function and neuron morphology. Specifically, there is marked atrophy of dendrites and dendritic spines on striatal medium spiny neurons (MSN), primary targets of inputs from nigral dopamine and cortical glutamate neurons, in advanced PD and rodent models of severe dopamine depletion. Dendritic spine loss occurs via dysregulation of intraspine Cav1.3 L-type Ca(2+)channels and can be prevented, in animal models, by administration of the calcium channel antagonist, nimodipine. The impact of MSN dendritic spine loss in the parkinsonian striatum on dopamine neuron graft therapy remains unexamined. Using unilaterally parkinsonian Sprague-Dawley rats, we tested the hypothesis that MSN dendritic spine preservation through administration of nimodipine would result in improved therapeutic benefit and diminished graft-induced behavioral abnormalities in rats grafted with embryonic ventral midbrain cells. Analysis of rotational asymmetry and spontaneous forelimb use in the cylinder task found no significant effect of dendritic spine preservation in grafted rats. However, analyses of vibrissae-induced forelimb use, levodopa-indu...Continue Reading

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Citations

Jul 12, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yiyue ZhangKathy Steece-Collier
Jun 19, 2013·Brain : a Journal of Neurology·Michael J HurleyDavid T Dexter
Feb 24, 2016·Frontiers in Cellular Neuroscience·Daniella Rylander Ottosson, Emma Lane
Jun 20, 2012·Basal Ganglia·Kathy Steece-CollierKatherine Soderstrom
Dec 3, 2011·Pharmacology & Therapeutics·Michael J Hurley, David T Dexter
Feb 28, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Haruo NishijimaMasahiko Tomiyama
Jan 29, 2010·The European Journal of Neuroscience·Erwan Bezard
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Mar 23, 2017·Journal of Neural Transmission·Scott C Vermilyea, Marina E Emborg
Mar 28, 2017·Molecular Neurobiology·Pratibha TripathiMahendra Pratap Singh
Sep 8, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Haruo NishijimaMasahiko Tomiyama
Aug 18, 2018·The European Journal of Neuroscience·Emma L Lane
Apr 20, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Kathy Steece-CollierFredric P Manfredsson
Jun 25, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Timothy J CollierKathy Steece-Collier
Nov 5, 2019·Frontiers in Neurology·Qiwei PengYan Xu
May 22, 2010·Current Opinion in Neurology·Laura E AllanPatrik Brundin
Nov 13, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Emma L LaneMariah J Lelos

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