Impact of Di-2-Ethylhexyl Phthalate Metabolites on Male Reproductive Function: a Systematic Review of Human Evidence

Current Environmental Health Reports
Birgit Bjerre HøyerIna Olmer Specht

Abstract

The purpose of this review is to systematically review the literature linking di-2-ethylhexyl phthalate (DEHP) exposure with effects on reproductive health in adult males. Thirty-three papers were included of which 28 were cross-sectional. Twenty-one papers investigated semen samples, 18 investigated reproductive hormones, and three studies investigated time to pregnancy. Studies revealed some but inconsistent indications that higher urinary DEHP metabolite levels are associated with an increase in the proportion of spermatozoa with damaged DNA and to a decrease in sperm concentration and motility. A negative association between DEHP metabolites and testosterone levels was more consistent. DEHP metabolites do not seem to be associated with a delay in time to pregnancy, but data are sparse. The studies on DEHP exposure and reproductive biomarkers in men converge to support the hypothesis that DEHP exposure is related to impaired male reproductive function. Longitudinal studies are needed to establish if the observed associations are causal.

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Citations

Jan 17, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Catheryne Chiang, Jodi A Flaws
Jan 12, 2020·Hormones : International Journal of Endocrinology and Metabolism·Despoina BliatkaDimitrios G Goulis
Oct 1, 2020·Analytical Methods : Advancing Methods and Applications·Qingsong ZhangZiping Zhang
Aug 9, 2020·International Journal of Environmental Research and Public Health·Angela GiulianiMarcella Reale
Mar 8, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sapna SedhaVivek K Bajpai
Mar 20, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Roya PournejatiHamid Reza Karbalaei-Heidari
Oct 8, 2021·Molecular Reproduction and Development·Inês MesquitaElisa Cairrao

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Software Mentioned

PRISMA
DEHP
EMBASE
REACH

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