Impact of diabetes mellitus on clinical outcomes in patients affected by Covid-19

Cardiovascular Diabetology
Celestino SarduRaffaele Marfella

Abstract

A possible association could exist between type 2 diabetes mellitus (T2DM) and Coronavirus-19 (Covid-19) infection. Indeed, patients with T2DM show high prevalence, severity of disease and mortality during Covid-19 infection. However, the rates of severe disease are significantly higher in patients with diabetes compared with non-diabetes (34.6% vs. 14.2%; p < 0.001). Similarly, T2DM patients have higher rates of need for Intensive Care Unit (ICU, 37.0% vs. 26.7%; p = 0.028). Thus, about the pneumonia of Covid-19, we might speculate that the complicated alveolar-capillary network of lungs could be targeted by T2DM micro-vascular damage. Therefore, T2DM patients frequently report respiratory symptoms and are at increased risk of several pulmonary diseases. In addition, pro-inflammatory pathways as that involving interleukin 6 (IL-6), could be a severity predictor of lung diseases. Therefore, it looks intuitive to speculate that this condition could explain the growing trend of cases, hospitalization and mortality for patients with T2DM during Covid-19 infection. To date, an ongoing experimental therapy with monoclonal antibody against the IL-6 receptor in Italy seems to have beneficial effects on severe lung disease and prognosi...Continue Reading

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Citations

Jun 18, 2020·Diabetes Care·Jamie Hartmann-BoyceKamlesh Khunti
Jul 22, 2020·Cardiovascular Diabetology·Antonio CerielloUNKNOWN “Diabetes and Cardiovascular Disease (D&CVD)” Study Group of the European Association for the Study of Diabetes (EASD)
Sep 10, 2020·International Journal of Molecular Sciences·Jairo Lumpuy-CastilloÓscar Lorenzo
Jul 24, 2020·Expert Opinion on Biological Therapy·Subramanian LoganathanShashank R Joshi
Dec 7, 2020·Cardiovascular Diabetology·Abdullah M AlguwaihesAnwar A Jammah
Sep 25, 2020·Diabetes Research and Clinical Practice·J ConwayA J Sinclair
Oct 16, 2020·Expert Opinion on Pharmacotherapy·Syed Shahzad HasanMuhammad Abdul Hadi
Dec 19, 2020·Frontiers in Immunology·Mohamed Abu-FarhaJehad Abubaker
Apr 1, 2021·BMC Cardiovascular Disorders·Khalid ChangalP Kasi Ramanathan
May 9, 2021·Cardiovascular Diabetology·Nunzia D'OnofrioRaffaele Marfella
Jun 3, 2021·International Journal of Molecular Sciences·Noha Mousaad ElemamNabil Sulaiman
Jun 8, 2021·Expert Review of Endocrinology & Metabolism·Aman RajpalDavid C Aron
Jun 25, 2021·ClinicoEconomics and Outcomes Research : CEOR·Enrico TorreGiacomo Matteo Bruno
Jul 22, 2021·Cardiovascular Diabetology·Hélène BihanEmmanuel Cosson
Jul 16, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Amit K VermaYamini Goyal
Dec 1, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Chikara GothongElias K Spanakis

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