Impact of diabetes on coronary stenosis and coronary artery calcification detected by electron-beam computed tomography in symptomatic patients

Diabetes Care
Masayuki HosoiSatoru Fujii

Abstract

Ischemic heart disease is a pivotal complication for diabetic patients. Electron-beam computed tomography (EBCT) represents the only noninvasive method that allows for accurate quantification of coronary artery calcification that reflects underlying atherosclerotic disease. Although coronary calcium score (CCS) cut points that predict the presence of angiographic stenosis have been established in nondiabetic individuals, it is not known whether coronary calcifications in diabetic patients are associated with the presence of significant coronary stenoses. In this study, we evaluated the relationship between coronary calcifications and angiographic stenosis in symptomatic patients with or without type 2 diabetes. In this study, 282 patients (204 men and 78 women) with chest pain, including 101 diabetic patients and 181 nondiabetic patients (mean age 63 +/- 9.6 years), underwent coronary angiography and EBCT with determination of CCS using Agatston's method. Luminal stenosis >or= 50% was defined as significant coronary stenosis. Angiography identified 205 patients with significant stenoses (89 of 101 diabetic patients, 114 of 181 nondiabetic patients). The sensitivity and specificity of EBCT to detect significant coronary stenosis...Continue Reading

References

Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·U FuchsP Wieniecki
May 1, 1982·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R E VlietstraT Killip
Jun 1, 1997·Journal of the American College of Cardiology·J A RumbergerR S Schwartz

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Citations

Mar 17, 2010·Cardiovascular Ultrasound·Victor K GohMatthew J Budoff
Nov 12, 2010·Diabetes Research and Clinical Practice·Alisha N WadeMuredach P Reilly
Mar 9, 2007·European Journal of Radiology·Ugur TopalAli Aydinlar
Jun 16, 2005·Diabetes, Obesity & Metabolism·K YamagamiS Fujii
Jun 13, 2009·JACC. Cardiovascular Imaging·Ammar SarwarKhurram Nasir
May 16, 2007·Circulation·Allen P BurkeRenu Virmani
Feb 11, 2004·Endocrine Reviews·V FonsecaI Jialal
Jul 25, 2012·Critical Pathways in Cardiology·Rajesh Tota-MaharajRoger S Blumenthal
Jul 1, 2018·Clinica Chimica Acta; International Journal of Clinical Chemistry·Bo LiTao Li

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