Impact of diabetes on long-term outcome in STEMI patients undergoing primary angioplasty with glycoprotein IIb-IIIa inhibitors and BMS or DES.

Journal of Thrombosis and Thrombolysis
Giuseppe De LucaEmilio Di Lorenzo

Abstract

Diabetes has been shown to be associated with worse survival and repeat revascularization (TVR) after primary angioplasty. Drug-eluting stent (DES) may offer benefits in terms of TVR, that may be counterbalanced by an higher risk of stent thrombosis, especially among STEMI patients. Aim of the current study was to evaluate the impact of diabetes on 5-year outcome in patients undergoing primary angioplasty with glycoprotein IIb-IIIa inhibitors in the era of DES. Our population is represented by STEMI patients undergoing primary angioplasty and stent implantation at a tertiary center with 24-h primary PCI capability within 12 h of symptom onset. All patients received glycoprotein IIb-IIIa inhibitors. No patient was lost to follow up. From 2003 to 2005, 270 STEMI patients were treated with DES (n = 180), or BMS (n = 90). A total of 69 patients had history of diabetes at admission (25.5%). At a follow-up of 1510 +/- 406 days, diabetes was associated with a higher rate of death (29.5 vs. 5.1%, P < 0.0001), reinfarction (24.1 vs. 9.1%, P < 0.0001), TVR (19.1 vs. 13.1%, P = 0.052), IST (17.2 vs. 6.8%, P < 0.001) and MACE (51.9 vs. 25.1%, P < 0.001). These results were confirmed in both patients receiving BMS or DES, except for TVR, wh...Continue Reading

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Citations

Dec 22, 2010·American Heart Journal·Leonardo De LucaGiuseppe De Luca
Apr 23, 2014·American Journal of Preventive Medicine·Monica VerdoiaUNKNOWN Novara Atherosclerosis Study Group (NAS)
Jul 28, 2011·Current Cardiology Reports·Emilio Di LorenzoRosario Sauro
Nov 11, 2014·Diabetes/metabolism Research and Reviews·Giuseppe De LucaDavid Antoniucci
Jan 1, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G De LucaH Suryapranata
Jul 15, 2015·Diabetes Research and Clinical Practice·Gabriella Di GiovineUNKNOWN Novara Atherosclerosis Study (NAS) group
Jun 28, 2014·Journal of Thrombosis and Thrombolysis·Giuseppe De LucaGregg W Stone
Dec 22, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Andreas BaumbachStephan Windecker
Mar 22, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Pilar Jimenez-QuevedoManel Sabate Tenas
Jul 8, 2015·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Giuseppe De LucaEmilio Di Lorenzo
May 22, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Giuseppe De LucaUNKNOWN Novara Atherosclerosis Study (NAS) group
Jan 1, 2013·Diabetes Care·Giuseppe De LucaUNKNOWN DESERT cooperation

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