Impact of diet and bariatric surgery on anti-Müllerian hormone levels

Human Reproduction
E Nilsson-CondoriB Friberg

Abstract

Do serum levels of anti-Müllerian hormone (AMH) change in women of reproductive age following dietary and surgery-induced weight loss? AMH levels increased after very low-calorie diet (VLCD) before surgery and decreased at 6 and 12 months after Roux-en-Y gastric bypass (RYGB), beyond expected normal age-related decline. Obesity has negative effects on fertility and IVF outcomes, and possibly also on AMH levels. AMH correlates to the number of growing follicles and is used to predict the response to IVF treatment. However, AMH might decrease after bariatric surgery. A prospective cohort study of 48 women followed first for 8 weeks preoperatively, then operated with RYGB and followed postoperatively for 1 additional year. Women aged 18-35 years with a mean (SD) BMI 40.9 (3.6) kg/m2 were included at baseline (BL). After the VLCD, a RYGB was performed. Body weight and height were measured at BL and 1 year postoperatively. Hormones were analysed at BL, after VLCD on the day before surgery, and at 6 and 12 months postoperatively. Median AMH levels were 30.0 pmol/L at BL and rose significantly after VLCD (median: 35.0 pmol/L; P = 0.014). Median AMH at 6 and 12 months postoperatively were significantly lower (19.5 and 18.0 pmol/L, resp...Continue Reading

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Citations

Aug 8, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jessica M StringerKarla J Hutt
Jan 23, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Vincenzo PiloneLuigi Schiavo
Aug 6, 2020·The Journal of Clinical Endocrinology and Metabolism·Estela BenitoJosé I Botella-Carretero
Mar 18, 2021·Obesity Surgery·Lillian DongKen Wing-King Loi
Nov 18, 2018·Metabolism: Clinical and Experimental·Charles J Glueck, Naila Goldenberg
Aug 14, 2021·Human Reproduction Update·Katinka M SnoekSam Schoenmakers

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