Impact of dietary genistein and aging on executive function in rats.

Neurotoxicology and Teratology
Steven L NeeseSusan L Schantz

Abstract

Genistein is an estrogenic soy isoflavone widely promoted for healthy aging, but its effects on cognitive function are not well-understood. We examined the cognitive effects of once daily oral genistein treatment at two doses (approximately 162 microg/kg/day low dose and a 323 microg/kg/day high dose) in ovariectomized young (7 month), middle-aged (16 month), and old (22 month) Long-Evans rats. Operant tasks including delayed spatial alternation (DSA), differential reinforcement of low rates of responding (DRL), and reversal learning that tap prefrontal cortical function were used to assess working memory, inhibitory control/timing, and strategy shifting, respectively. At the conclusion of cognitive testing, brains were collected and relative densities of D1 and D2 dopamine receptors and dopamine transporter (DAT) were measured in the prefrontal cortex. On the DSA task, the high dose old group performed worse than both the high dose young and middle-aged groups. On the DRL task, the high dose of genistein resulted in a marginally significant impairment in the ratio of reinforced to non-reinforced lever presses. This effect was present across age groups. Age effects were also found as old rats performed more poorly than the youn...Continue Reading

References

Sep 1, 1990·Brain Research Bulletin·M MorissetteT Di Paolo
Nov 1, 1994·Pharmacology, Biochemistry, and Behavior·S RouxR D Porsolt
Jun 1, 1997·Brain Research. Molecular Brain Research·R BosséT Di Paolo
Aug 1, 1997·Behavioural Brain Research·J G HerndonR J Killiany
Dec 5, 1997·The Journal of Comparative Neurology·P J ShughrueI Merchenthaler
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·T M HagenB N Ames
Nov 5, 1998·Psychoneuroendocrinology·L E Carlson, B B Sherwin
Aug 6, 1999·Hormones and Behavior·A LacreuseM B Moss
Feb 7, 2001·The American Journal of Psychiatry·P M MakiS M Resnick
Jun 19, 2001·Psychoneuroendocrinology·P A KeenanG J Moore
Sep 25, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Nathan C TwaddleDaniel R Doerge
Jun 7, 2003·Menopause : the Journal of the North American Menopause Society·Donna Kritz-SilversteinMathias A B Bressel
Jun 18, 2003·Neuroscience·A V Savonenko, A L Markowska
Dec 4, 2003·Neurobiology of Aging·Michael F SalvatoreGreg A Gerhardt
Dec 11, 2003·Journal of Agricultural and Food Chemistry·Drazen KostelacKarlis Briviba
Jan 30, 2004·Neurobiology of Aging·Barbara Shukitt-HaleJames A Joseph
Apr 16, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stefan O MuellerKenneth S Korach
Aug 25, 2004·Behavioural Brain Research·Jennifer K WideLiisa A M Galea
Mar 18, 2005·Menopause : the Journal of the North American Menopause Society·Sandra E FileHelen Wiseman

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Citations

Feb 4, 2014·Maturitas·Mira SoniEef Hogervorst
Sep 28, 2012·Human Brain Mapping·Marian van der MeulenPatrik Vuilleumier
Feb 7, 2013·Menopause : the Journal of the North American Menopause Society·Russell T TurnerWilliam G Helferich
Nov 27, 2018·Journal of Alzheimer's Disease : JAD·Tauqeerunnisa SyedaClaudia Perez-Cruz

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