Impact of differences in diagnostic criteria when determining the incidence of contact lens-associated keratitis

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Nathan Efron, Philip B Morgan

Abstract

The purpose of this study is to examine the effect of differences in within-study and between-study diagnostic criteria in determining the incidence of contact lens-associated keratitis. We applied the sets of criteria for "microbial keratitis" as described in five previous studies to the dataset of Morgan et al., which documents 118 cases of contact lens-associated keratitis across a wide range of clinical severities. For each set of criteria, the incidence of contact lens-associated keratitis was calculated for the following five lens type/modality combinations: daily-wear rigid, daily-wear daily disposable hydrogel, daily-wear hydrogel, extended-wear hydrogel, and extended-wear silicone hydrogel. The effect of varying the clinical severity score for the differentiation of nonsevere versus severe keratitis was also examined with respect to the dataset of Morgan et al. The size and location of the corneal infiltrative events identified as representing "microbial keratitis" for each of the different sets of criteria are illustrated in a series of cartograms. A key between-study difference in the incidence values calculated for the various sets of criteria relates to the categories of extended-wear hydrogel and extended-wear sil...Continue Reading

References

Sep 21, 1989·The New England Journal of Medicine·E C PoggioK R Kenyon
Jun 15, 1988·American Journal of Ophthalmology·R M SteinP R Laibson
Aug 24, 2002·Eye·D S C LamUNKNOWN Hong Kong Microbial Keratitis Study Group
May 30, 2003·Eye & Contact Lens·Murali K AasuriVinod M Kumar
May 30, 2003·Eye & Contact Lens·P WuM D P Willcox
Mar 19, 2005·The British Journal of Ophthalmology·P B MorganA B Tullo
Jun 25, 2005·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Nathan EfronAndrew B Tullo

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Citations

Aug 16, 2006·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Nathan Efron, Philip B Morgan
Dec 14, 2006·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Suzanne M J Fleiszig
Jul 3, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Lisa KeayFiona Stapleton
Apr 17, 2007·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Loretta Szczotka-Flynn, Mireya Diaz
Apr 17, 2007·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Fiona StapletonNerida Cole
Feb 24, 2007·BMC Bioinformatics·Shuangge MaJian Huang
Sep 20, 2008·BMC Bioinformatics·Taewon LeeRobert R Delongchamp

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