Impact of different palliative systemic treatments on skeletal muscle mass in metastatic colorectal cancer patients

Journal of Cachexia, Sarcopenia and Muscle
Sophie A KurkAnne M May

Abstract

Observational studies suggest that loss of skeletal muscle mass (SMM) is associated with chemotherapy-related toxicity, poor quality of life, and poor survival in metastatic colorectal cancer (mCRC) patients. Little is known about the evolution of SMM during palliative systemic therapy. We investigated changes in SMM during various consecutive palliative systemic treatment regimens using repeated abdominal computed tomography scans of mCRC patients who participated in the randomized phase 3 CAIRO3 study. In the CAIRO3 study, mCRC patients with stable disease or better after 6 cycles of first-line treatment with capecitabine + oxaliplatin + bevacizumab (CAPOX-B) were randomized between maintenance treatment with capecitabine + bevacizumab (CAP-B) or observation. Upon first disease progression, in both groups, CAPOX-B or other treatment was reintroduced until the second disease progression, which was the primary study endpoint. We analysed 1355 computed tomography scans of 450 (81%) CAIRO3 patients (64 ± 9.0 years, CAP-B n = 223; observation n = 227) for SMM at four time points (i.e. prior to the start of pre-randomization initial treatment, at randomization, and at first and at second disease progression) using the Slice-o-matic...Continue Reading

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Citations

Feb 29, 2020·Journal of Cachexia, Sarcopenia and Muscle·Jeroen W G DerksenAnne M May
Nov 24, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Utku OflazogluM Oktay Tarhan
Feb 26, 2019·ESC Heart Failure·Andrew J Stewart Coats
Mar 30, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·O KöstekB Erdoğan
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Aug 5, 2020·Targeted Oncology·Tomas BuchlerIgor Richter
Dec 5, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Huaiying SuLijing Shi
May 17, 2019·Journal of Cachexia, Sarcopenia and Muscle·Sophie KurkAnne May
Sep 14, 2019·The American Journal of Clinical Nutrition·Sophie A KurkAnne M May
Sep 29, 2020·The Proceedings of the Nutrition Society·Aoife M Ryan, Erin S Sullivan
Feb 11, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A van der WerfM A E de van der Schueren

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Methods Mentioned

BETA
imaging techniques

Clinical Trials Mentioned

NCT00442637

Software Mentioned

‐ o
TomoVision
MeVis
Slice
‐ matic

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