Impact of Digoxin on Mortality in Patients With Atrial Fibrillation Stratified by Heart Failure: Findings From Gulf Survey of Atrial Fibrillation Events in the Middle East

Journal of Cardiovascular Pharmacology and Therapeutics
Ibrahim Al-ZakwaniHaitham Amin

Abstract

The use of digoxin in patients having atrial fibrillation (AF) with or without heart failure (HF) is not without controversy. The aim of this study was to examine the impact of digoxin therapy on mortality stratified by HF. Gulf Survey of Atrial Fibrillation Events was a prospective, multinational, observational registry of consecutive patients with AF recruited from the emergency department of 23 hospitals in 6 countries in the Middle East. Patients were recruited between October 2009 and June 2010 and followed up for 1 year after enrollment. Analyses were performed using univariate and multivariate statistical techniques. The study included a total of 1962 patients with AF, with an overall mean age of 56 ± 16 years, and 52% (n = 1026) were males. At hospital discharge, digoxin was prescribed in 36% (n = 709) of the patients, whereas HF was present in 27% (n = 528) of the cohort. A total of 225 (12.1%) patients died during the 12-month follow-up period after discharge (5.3% [n = 104] were lost to follow-up). Patients with HF were consistently associated with higher mortality at 1 month (5.1% vs 2.1%; P < .001), 6 months (17.2% vs 5.0%; P < 0.001), and 12 months (24.3% vs 7.6%; P < .001) when compared to those without HF. When ...Continue Reading

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Citations

Oct 28, 2016·Journal of Clinical Pharmacy and Therapeutics·M BitekerC Kırma
Oct 26, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Seema Patel
Aug 22, 2017·International Journal of Clinical Pharmacy·Alaa Abdullah RahhalLylia Mekideche
May 12, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Ying GaoChangsheng Ma
Jun 27, 2019·Current Cardiology Reviews·Filipe FerrariRicardo Stein
Oct 19, 2021·Frontiers in Cardiovascular Medicine·Xiaoxu WangKun Zhao

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