Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis

Journal of Hepatology
Graham R FosterHCV Research, UK

Abstract

All oral direct acting antivirals (DAAs) effectively treat chronic hepatitis C virus (HCV) infection, but the benefits in advanced liver disease are unclear. We compared outcomes in treated and untreated patients with decompensated cirrhosis. Patients with HCV and decompensated cirrhosis or at risk of irreversible disease were treated in an expanded access programme (EAP) in 2014. Treatment, by clinician choice, was with sofosbuvir, ledipasvir or daclatasvir, with or without ribavirin. For functional outcome comparison, untreated patients with HCV and decompensated cirrhosis who were registered on a database 6months before treatment was available were retrospectively studied. Primary endpoint was sustained virological response 12weeks post antiviral treatment (treated cohort) and the secondary endpoint (both cohorts) was adverse outcomes (worsening in MELD score or serious adverse event) within 6months. 467 patients received treatment (409 decompensated cirrhosis). Viral clearance was achieved in 381 patients (81.6%) - 209 from 231 (90.5%) with genotype 1 and 132 from 192 (68.8%) with genotype 3. MELD scores improved in treated patients (mean change -0.85) but worsened in untreated patients (mean+0.75) (p<0.0001). Patients with...Continue Reading

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References

Dec 27, 2012·JAMA : the Journal of the American Medical Association·Adriaan J van der MeerHarry L A Janssen
Apr 15, 2014·The New England Journal of Medicine·Fred PoordadBarry Bernstein
Apr 15, 2014·The New England Journal of Medicine·Nezam AfdhalUNKNOWN ION-2 Investigators
Apr 15, 2014·The New England Journal of Medicine·Nezam AfdhalUNKNOWN ION-1 Investigators
Jan 24, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David R NelsonUNKNOWN ALLY-3 Study Team
Apr 8, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Rajender ReddyNezam Afdhal
May 20, 2015·Gastroenterology·Michael CharltonUNKNOWN SOLAR-1 Investigators
Sep 2, 2015·Journal of Hepatology·Jessica K DysonStuart McPherson
Nov 17, 2015·The New England Journal of Medicine·Michael P CurryUNKNOWN ASTRAL-4 Investigators

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Citations

Mar 5, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Roberta D'Ambrosio, Massimo Colombo
May 24, 2016·Journal of Hepatology·Luca Saverio BelliUNKNOWN European Liver and Intestine Association (ELITA)
Jun 16, 2016·The Lancet Infectious Diseases·Daniel J FelmleeThomas F Baumert
Aug 6, 2016·Journal of Clinical and Experimental Hepatology·Pankaj PuriSwastik Agrawal
Jul 13, 2016·The Journal of Antimicrobial Chemotherapy·Maria-Carlota LondoñoJose-Maria Miró
Jul 16, 2016·Journal of Hepatology·Jean-Charles Nault, Massimo Colombo
May 1, 2016·Journal of Hepatology·Emma GrayUNKNOWN Irish Hepatitis C Outcomes and Research Network (ICORN)
Nov 9, 2016·Hepatitis Monthly·Seyed Moayed Alavian, Mohammad Saeid Rezaee-Zavareh
Sep 20, 2016·Journal of Hepatology·Darius MoradpourMichael P Manns
Sep 20, 2016·Journal of Hepatology·Adriaan J van der Meer, Marina Berenguer
Sep 27, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu
Oct 19, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·I CarmonaM Romero-Gómez
Nov 18, 2016·Journal of Comparative Effectiveness Research·Emma GrayAisling O'Leary
Nov 15, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Floor A C BerdenJoost P H Drenth
Nov 20, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Maria Francesca DonatoUNKNOWN ITACOPS-SOF Bridging Study Group
Jan 5, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·François Durand, Claire Francoz
Jan 5, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Marcus M MückeStefan Zeuzem
Dec 25, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jennifer A FlemmingNorah A Terrault
Mar 7, 2017·Alimentary Pharmacology & Therapeutics·M GuarinoA Andriulli
Feb 9, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Christophe HézodeJean-Pierre Bronowicki
Dec 26, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ju Dong YangMichael D Leise
Feb 18, 2017·Transplantation·Elizabeth C Verna, Robert S Brown
Feb 9, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carlos Fernández CarrilloJosé Luis Calleja
Mar 21, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Duminda Suraweera, Sammy Saab
Mar 23, 2017·Journal of Hepatology·Luca S BelliMario Strazzabosco
Jul 7, 2017·CA: a Cancer Journal for Clinicians·Harrys A TorresVincent Mallet
Jul 22, 2017·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Fanpu JiZongfang Li
Dec 6, 2017·Alimentary Pharmacology & Therapeutics·G W McCaughanUNKNOWN Australian Liver Association Clinical Research Network
Feb 11, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Bruno RocheDidier Samuel
Feb 11, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Marcus M MückeStefan Zeuzem
Aug 12, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Paola CarraiUNKNOWN ITACOPS study group
Oct 13, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Neil Mehta, Francis Y Yao

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