Impact of direct-acting antivirals for HCV on mortality in a large population-based cohort study.

Journal of Hepatology
Naveed Z JanjuaMel Krajden

Abstract

We evaluated the effect of direct-acting antiviral (DAA)-induced sustained virologic response (SVR) on all-cause, liver- and drug-related mortality in a population-based cohort in British Columbia, Canada. We used data from the British Columbia Hepatitis Testers Cohort, which includes people tested for HCV since 1990, linked with data on medical visits, hospitalizations, prescription drugs and mortality. We followed people who received DAAs and people who did not receive any HCV treatment to death or December 31, 2019. We used inverse probability of treatment weighting to balance the baseline profile of treated and untreated individuals and performed multivariable proportional hazard modelling to assess the effect of DAAs on mortality. Our cohort comprised 10,851 people treated with DAAs (SVR 10,426 [96%], no-SVR: 425) and 10,851 matched untreated individuals. Median follow-up time was 2.2 years (IQR 1.3-3.6; maximum 6.2). The all-cause mortality rate was 19.5/1,000 person-years (PY) among the SVR group (deaths = 552), 86.5/1,000 PY among the no-SVR group (deaths = 96), and 99.2/1,000 PY among the untreated group (deaths = 2,133). In the multivariable model, SVR was associated with significant reduction in all-cause (adjusted h...Continue Reading

References

Jun 22, 2012·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Robert P MyersJordan J Feld
Apr 4, 2013·BMC Public Health·Amanda YuMel Krajden
Jul 21, 2016·BMC Infectious Diseases·Naveed Zafar JanjuaMel Krajden
Jul 28, 2016·American Journal of Epidemiology·Mohammad Ehsanul KarimUNKNOWN Long-Term Benefits and Adverse Effects of Beta-Interferon for Multiple Sclerosis (BeAMS) Study Group
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·UNKNOWN Polaris Observatory HCV Collaborators
Jun 24, 2017·Gastroenterology·Fasiha KanwalHashem B El-Serag
Jul 28, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lisa I BackusLarry A Mole
Jan 30, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lisa I BackusLarry A Mole
Feb 27, 2018·The International Journal on Drug Policy·Naveed Zafar JanjuaUNKNOWN BC Hepatitis Testers Cohort Team
Apr 13, 2019·Hepatology Communications·Naveed Z JanjuaUNKNOWN British Columbia Hepatitis Testers Cohort Team
Jun 24, 2019·The International Journal on Drug Policy·Mel KrajdenNaveed Z Janjua
Mar 14, 2020·JAMA : the Journal of the American Medical Association·Mats J Stensrud, Miguel A Hernán

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