Impact of donor hepatitis C virus infection status on death and need for liver transplant in hepatitis C virus-positive kidney transplant recipients

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
L M KucirkaD L Segev

Abstract

Only 29% of deceased donor kidney recipients with hepatitis C virus (HCV) receive HCV-positive (HCV+) kidneys. These kidneys are discarded 2.5 times more often than their HCV-negative (HCV-) counterparts, possibly due to the sense that an HCV+ kidney may adversely affect recipient liver function. The goals of this study were to characterize liver disease in HCV+ kidney recipients and compare rates of liver-related outcomes by kidney donor HCV status. Observational cohort study. 6,250 patients with HCV who had a kidney transplant in 1995-2008 as captured in the United Network for Organ Sharing (UNOS) database. Liver-related outcomes were assessed by cross-linking with the liver waitlist and transplant data sets. HCV status of transplanted kidney. Joining the liver waitlist, receiving a liver transplant, death. Time to event. Only 63 (1%) of HCV+ kidney recipients eventually joined the liver waitlist during the 13-year study period. Those who received HCV+ kidneys had a 2.6-fold higher hazard of joining the liver list (P < 0.001); however, the absolute difference in rate of listing between recipients of HCV- and HCV+ kidneys was <2%. This is consistent with findings of only 2% lower patient survival at 3 years in HCV+ patients re...Continue Reading

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Citations

Mar 25, 2014·World Journal of Gastroenterology : WJG·Massimiliano VerouxPierfrancesco Veroux
Oct 14, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N A Terrault, P G Stock
Aug 6, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S Baid-AgrawalM Muche
Nov 11, 2014·Clinical Transplantation·Edie Y ChanJames D Perkins
Jun 22, 2016·Current Opinion in Organ Transplantation·Denise J LoNicole A Turgeon
Oct 13, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stevan A Gonzalez, James F Trotter
Dec 10, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN AASLD-IDSA Hepatitis C Guidance Panel
Feb 13, 2018·Current Opinion in Organ Transplantation·AnnMarie LiapakisJosh Levitsky
Nov 4, 2017·Journal of Clinical Gastroenterology·Veronica Angulo-DiazAnnMarie Liapakis
Jan 28, 2015·World Journal of Hepatology·Ahmad Najib AzmiRosmawati Mohamed
May 31, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J LevitskyM Volk
Aug 29, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kimberly Brown
Jul 7, 2018·Current Treatment Options in Infectious Diseases·Ashton A Shaffer, Christine M Durand
Aug 25, 2018·Hemodialysis International·John WigneswaranAllen R Nissenson
Jun 1, 2019·Current Transplantation Reports·Luckmini LiyanageChristine M Durand
May 24, 2018·Current Infectious Disease Reports·Lucy Somerville, Karen Doucette
Jan 1, 2016·Der Nephrologe·H GuberinaO Witzke
Feb 11, 2020·JHEP Reports : Innovation in Hepatology·Elizabeth C VernaRobert S Brown

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