Impact of donor variables on heart transplantation outcomes in mechanically bridged versus standard recipients†

Interactive Cardiovascular and Thoracic Surgery
Marian UrbanGuy MacGowan

Abstract

This study aimed to quantify the impact of donor variables on post-heart transplantation mortality and morbidity in recipients with and without a pretransplant left ventricular assist device (LVAD). This is a prospective cohort study of the ISHLT Transplant Registry that includes all primary heart transplants in adult recipients (January 2005-June 2013, n = 15 532). All recipients were divided into patients with a durable continuous-flow LVAD (LVAD recipient, n = 3315) and without mechanical support (standard recipient, n = 12 217). Donors were classified as high risk (n = 3751) and low risk (n = 11 781). Transplants were categorized into low-risk donor/standard recipient (n = 9214), high-risk donor/standard recipient (n = 3003), low-risk donor/LVAD recipient (n = 2567) and high-risk donor/LVAD recipient (n = 748). Outcomes prior to discharge, survival at 5 years and freedom from complications were computed for each group. LVAD recipients experienced more episodes of infection, stroke and acute rejection with both low- (P < 0.001, P < 0.001, P < 0.001) and high-risk donors (P < 0.001, P = 0.008, P = 0.028) prior to transplant discharge. Within standard recipients, a higher rate of primary graft failure (P = 0.035), infection (P...Continue Reading

References

Sep 1, 2004·The Annals of Thoracic Surgery·Dipin GuptaSatoshi Furukawa
Oct 22, 2008·Transplantation Proceedings·C I TsaoS S Wang
Mar 28, 2009·The Annals of Thoracic Surgery·Mark J RussoYoshifumi Naka
Oct 7, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Josef StehlikUNKNOWN Cardiac Transplant Research Database Group
Nov 19, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Eric S WeissAshish S Shah
Dec 20, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jacqueline M SmitsAndreas Zuckermann
Mar 16, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kiran K KhushManisha Desai
Feb 9, 2013·Circulation. Heart Failure·Kiran K KhushBenjamin A Goldstein
Jul 12, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Evan P Kransdorf, Josef Stehlik
Mar 6, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Henrik BergenfeldtJohan Nilsson
Aug 7, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lars H LundUNKNOWN International Society for Heart and Lung Transplantation

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Citations

Jan 14, 2020·Seminars in Cardiothoracic and Vascular Anesthesia·Nirvik PalAaron C Lim
Jan 28, 2021·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee

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